慢性肾衰竭大鼠甲状旁腺激素对心脏的影响  

Influence of Parathyroid Hormone to Heart in Chronic Renal Failure Rats

作　　者：王莹[1] 曹文静[1] 张凤娟[1] 

机构地区：[1]河南职工医学院护理系,河南郑州451191

出　　处：《河南职工医学院学报》2011年第1期6-7,共2页Journal of Henan Medical College For Staff and Workers

摘　　要：目的观察慢性肾衰竭(CRF)大鼠甲状旁腺激素(PTH)对心脏的影响情况,旨在为慢性肾衰竭心血管并发症的临床早期诊断和治疗提供理论依据。方法雌雄各半Wistar大鼠24只,先随机分为正常组6只和对照组18只。对照组给予灌服腺嘌呤建立CRF模型。确定模型成熟后,将其进一步分为CRF组和治疗组。治疗组给予罗钙全治疗10周,观察治疗前后治疗组大鼠PTH和cTnI的变化情况。结果治疗组大鼠给予罗钙全治疗后,血清PTH和cTnI均有明显的降低。结论在治疗CRF心血管并发症时,应重视降低血清PTH的作用。Objective To observe the influence of parathyroid hormone to heart in chronic renal failure（CRF） rats,and to provide theory for early therapy in CRF heart complications.Methods Firstly,24 wistar rats were divided into 2 groups at random： normal group（6） and others（18）.Then set up CRF model by feeding Adenine.CRF rats were divided into 2 groups at random,including： CRF group and treatment group.We detected PTH and cTnI with ELISA and renal function before and after therapy.Results There is significant decrease in PTH and cTnI in treatment group rats.Conclusion We should reconstruct PTH in the therapy of cardiac damage in CRF

关 键 词：慢性肾衰竭 甲状旁腺激素 肌钙蛋白 

分 类 号：R54[医药卫生—心血管疾病]