自体骨髓单个核细胞移植治疗慢性下肢缺血性疾病的临床研究  

Clinical research of autologous bone marrow mononuclear cell transplantation for chronic lower extremity ischemic disease

作　　者：易海[1] 张玲[1] 王蓉[1] 苏毅[1] 

机构地区：[1]成都军区总医院血液科,四川成都610083

出　　处：《实用临床医药杂志》2011年第3期31-33,共3页Journal of Clinical Medicine in Practice

摘　　要：目的观察自体骨髓单个核细胞移植对慢性下肢缺血性疾病的治疗效果。方法选取2008年10月~2010年10月期间本院收治的慢性下肢缺血性疾病患者13例,通过采集患者自体骨髓,密度离心法分离骨髓单个核细胞,多点注射至患肢局部,2月后观察患肢疼痛、冰冷、麻木、间歇性跛行等主观指标改善情况及经皮氧分压,踝肱指数,溃疡面积等客观指标改善情况。结果 13例患者均顺利完成了移植手术,2月后评价,患肢疼痛的改善率为87.5%,冰冷感的改善率为86.4%,麻木的改善率为72.2%,间歇性跛行的改善率为66.7%,经皮氧分压移植前为（20.9±4.4）mmHg,移植2月后为（36.8±7.5）mmHg,改善率为87.5%,踝肱指数移植前为0.34±0.14,移植2月后为0.57±0.17,改善率为83.3%,溃疡改善率为80%。结论 自体骨髓单个核细胞移植治疗慢性下肢缺血性疾病是安全和有效的。Objective To observe the effects of autologous bone marrow mononuclear cell transplantation for chronic lower extremity ischemic disease.Methods Thirteen patients from our department between Oct 2008 to Oct 2010 who suffered from chronic lower limb ischemia were selected,Bone marrows were collected and bone marrow mononuclear cells were acquired by density centrifugation.Bone marrow mononuclear cells were transplanted by local multi-point injection to the affected limbs.After 2 months,leg pain,cold,numbness,intermittent claudication,percutaneous oxygen pressure,ankle brachial index,ulcer area of these patients were detected.Results Transplantation was all completed successfully for the 13 patients.After 2 months,the improvement rate of limb pain was 87.5%,the improvement rate of cold sense was 86.4%,the improvement rate of numbness was 72.2% and the improvement rate of intermittent claudication was 66.7%.Transcutaneous oxygen pressure before transplantation was（20.9±4.4） mmHg,2 months after the transplantation was（36.8±7.5） mmHg,the improvement rate was 87.5%,ankle brachial index before transplantation was 0.34±0.14,2 months after transplantation was 0.57±0.17,the improvement rate was 83.3%.And the ulcer improvement rate was 80%.Conclusion Autologous bone marrow mononuclear cell transplantation for chronic lower limb ischemia is safe and effective.

关 键 词：单个核细胞 慢性下肢缺血性疾病 经皮氧分压 踝肱指数 

分 类 号：R457.7[医药卫生—治疗学]