恩诺沙星微囊体外溶出度的研究  

Research on Dissolution Rate of Enrofloxacin Microcapsule

作　　者：尹烨华[1] 梁文涛[1] 余永鹏[1] 马江耀[1] 郭伟干[1] 唐兴刚[1] 孙俊颖[1] 陈玉婷[1] 彭新宇[1] 

机构地区：[1]广东省农业科学院兽医研究所,广州510640

出　　处：《中国兽药杂志》2011年第2期20-22,共3页Chinese Journal of Veterinary Drug

摘　　要：为了遮蔽恩诺沙星的苦味,改善恩诺沙星的适口性,利用沸腾包衣工艺对恩诺沙星进行包衣,制成恩诺沙星微囊,作为恩诺沙星口服给药制剂的原料。通过体外溶出度试验,测定了恩诺沙星微囊在猪人工胃液中的溶出度。结果表明:不同粒径的恩诺沙星微囊在猪人工胃液中均能迅速溶出,60 min即接近最大溶出度。微囊粒径大小对恩诺沙星的溶出有一定影响,粒径越小溶出越快,最大溶出度也越高。To obstruct bitter taste of enrofloxacin and improve its palatability,enrofloxacin was coated to be microcapsule for raw material of oral preparation.According to the test of dissolution rate in vitro,dissolution of enrofloxacin microcapsule in artificial gastric juice was determined.The results showed that all different diameter particle could dissolve quickly,the dissolution rate close to maximum value in 60 min.The smaller particle,the higher dissolution rate.

关 键 词：恩诺沙星 微囊 溶出度 

分 类 号：S859.79[农业科学—临床兽医学]