胰岛素样生长因子Ⅱ及碱性成纤维细胞生长因子在肾上腺疾病组织中的表达  

Expression and significance of IGF-Ⅱ and bFGF in adrenal disease

作　　者：张楚龙[1,2] 胡卫列[2] 黄成[2] 

机构地区：[1]南方医科大学在读硕士研究生,广东省广州510010 [2]广州军区广州总医院泌尿外科

出　　处：《中国基层医药》2011年第4期482-484,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨胰岛素样生长因子Ⅱ（IGF-Ⅱ）及碱性成纤维细胞生长因子（bFGF）在肾上腺疾病发生过程中所起的作用及临床意义。方法收集标本分为肾上腺嗜铬细胞瘤组、皮髓质增生组、皮质腺瘤组、正常肾上腺组织组各15例，采用免疫组织化学二步法检测各组IGF-Ⅱ及bFGF蛋白在各组的表达情况。结果IGF-Ⅱ及bFGF蛋白表达水平在四组中表达差异均有统计学意义（均P〈0．05），表达率从高到低依次为人肾上腺嗜铬细胞瘤组、肾上腺皮髓质增生组、肾上腺皮质腺瘤组，而正常肾上腺组皆地低表达或不表达。各组中IGF-Ⅱ及bFGF蛋白表达均呈正相关（均P〈0．05）。前三组IGF-Ⅱ及bFGF蛋白阳性细胞面积与血压均存在正相关关系（均P〈0．05）。结论IGF-Ⅱ及bFGF蛋白在人肾上腺皮髓质增生症、皮质腺瘤，特别是嗜铬细胞瘤的发生发展中及其高血压的形成可能起重要作用，同时二者之间存在协同作用。Objective To investigate the expressions and significance of insulin-like growth factor Ⅱ and basic fibroblast growth factor in adrenal disease. Methods The experiment was divided into groups of adrenal pheochro-mocytoma,eorticomedullary hyperplasia, cortical adenoma, normal adrenal tissue. Every group was 15 cases. Expression of IGF- Ⅱ and bFGF were detected by immunohistochemistry in adrenal disease. Results There was a significant difference among the four groups （ all P 〈 0.05 ）. IGF- Ⅱ and bFGF expression was higher in adrenal pheochromocytoma tissue than that of corticomedullary hyperplasia and cortical adenoma. In the normal adrenal gland group was low expression or no expression. In each group, IGF- Ⅱ and bFGF protein expression was positively correlated （ all P 〈 0. 05）. There also was a positive correlation between IGF-Ⅱ and bFGF positive cell and blood pressure in adrenal pheochromocytoma, corticomedullary hyperplasia and cortical adenoma （ all P 〈 0. 05 ）. Conclusion IGF- Ⅱ and bFGF protein were closely related to the occurrence and development of human adrenal corticomeduUary hyperplasia, cortical adenoma,pheochmmecytoma, and played a role in hypertension caused by them. At the same time there was a synergistic effect between the IGF- Ⅱ and bFGF protein in adrenal disease.

关 键 词：肾上腺疾病 胰岛素样生长因子Ⅱ 碱性成纤维细胞生长因子 

分 类 号：R5[医药卫生—内科学]