Polypeptide dendrimers: Self-assembly and drug delivery  

作　　者：XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin GU ZhongWei 

机构地区：[1]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

出　　处：《Science China Chemistry》2011年第2期326-333,共8页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China (973 Program,2011CB606206);National High-Tech Research & Development Program of China (863 Program,2007AA021801);National Natural Science Foundation of China (50633020 & 50830105);Sichuan Youth Science & Technology Foundation (07ZQ026-013);Open Fund of Engineering Research Center of Biomass Materials,Ministry of Education (2010LF4002)

摘　　要：Amphiphilic dendritic poly（glutarnic acid）-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly（glutamic acid） as the macroinitiator in the ring-opening polymerization of NCA-Phe. The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly（glutamic acid） segments as shell. The biocompatibility of the micelles was studied. The release of the anticancer drug doxorubicin from the micelles was investigated in vitro. The results showed that the sustaining release of the drug could last for 60 h. The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells, 75% cancer cells were killed under appropriate in vitro incubation.Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe.The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell.The biocompatibility of the micelles was studied.The release of the anticancer drug doxorubicin from the micelles was investigated in vitro.The results showed that the sustaining release of the drug could last for 60 h.The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells,75% cancer cells were killed under appropriate in vitro incubation.

关 键 词：serf-assembly dendritic polypeptide block copolymer drug delivery 

分 类 号：TQ317[化学工程—高聚物工业] TB383[一般工业技术—材料科学与工程]