脂质体制备方法及相关性质的研究概况  

Research advances in liposomes preparatians and related properties

作　　者：王文节[1] 唐小牛[1] 杨江华[1] 

机构地区：[1]芜湖市高教园区皖南医学院人体寄生虫学教研室,安徽芜湖241100

出　　处：《现代医药卫生》2011年第5期708-710,共3页Journal of Modern Medicine & Health

基　　金：国家自然科学基金青年基金(NO.30700694);安徽省自然科学基金(NO.kj2008B328)联合资助

摘　　要：脂质体制备剂技术发展迅速并逐渐完善,其多种制备方法各有利弊。评价脂质体质量的指标有外观、粒径分布、包封率和渗漏率等;稳定性也是制备脂质体过程中需要考虑的另一个重要因素。逆相蒸发法是制备脂质体的一种常用方法。本文从近几年逆相蒸发法制备脂质体及其质量评价和稳定性研究三方面作一综述。The technology of preparing liposomes develops rapidly and improves gradually,the variety of preparation methods have their advantage and shortcoming.The reverse-phase evaporation is a common method of liposomes preparing.Evaluation indicators of the liposomes＇quality include appearanc,particle size distribution,encapsulation rate and leakage rate,and so on.Stability is also an important factor to be considered in the preparation of liposomes.In this paper,the method of preparing liposomes by reverse-phase evaporation and its quality evaluation and stability are reviewed.

关 键 词：脂质体 逆相蒸发法 质量评价 稳定性 

分 类 号：R9[医药卫生—药学]