花椒总生物碱镇痛、抗炎、止痒作用研究  

Analgesic,Anti-inflammatory and Antipruritic Effects of Zanthoxylum Alkaloids

作　　者：石雪萍[1] 张卫明[1] 张鸣镝[2] 关荣琴[2] 

机构地区：[1]南京野生植物综合利用研究院,江苏南京210042 [2]吉林大学军需科技学院,吉林长春130062

出　　处：《中国野生植物资源》2011年第1期46-49,共4页Chinese Wild Plant Resources

基　　金：国家"十一五"科技支撑计划重点课题(2006BAD06B02)

摘　　要：目的:研究花椒生物碱镇痛、抗炎及止痒作用。方法:分别采用热板法考察其镇痛作用二甲苯致炎法考察其抗炎作用、低分子右旋糖酐-40诱发小鼠皮肤瘙痒研究其止痒作用。结果:中、高浓度的花椒生物碱对小鼠热刺激引起的疼痛具有较强的镇痛作用;高浓度的花椒生物碱能较强抑制二甲苯所致小鼠耳肿胀,并能缓解分子右旋糖酐-40诱发的小鼠皮肤瘙痒。具有较强的抗炎、止痒作用。结论:花椒生物碱具有较强的镇痛、抗炎、止痒作用。Objective： To study the analgesic anti -inflammatory, and antipruritic efects of Zanthoxylum alkaloids. Methods ： The 55 ℃ hot plate test in mice were used to detect the analgesia. The anti - inflam- matory effects were detected with xylene - induced ear swelling and carrageenan hind paws edema in mice and the itch - scratch responses were induced by IV dextran - 40 in mice. Results ： The Zanthoxylum alkaloids raised mouse pain threshold in high and middle dose manner. The Zanthoxylum alkaloids inhibited mouse ears edema significantly in a dose - dependent manner. Zanthoxylum alkaloids also significantly decreased paroxysm frequency and the duration of the itch. Conclusions ： The Zanthoxylum alkaloids possess analgetic anti- inflammatory, and antipruritic effects.

关 键 词：花椒 生物碱 镇痛 抗炎 止痒 

分 类 号：S567[农业科学—中草药栽培]