N-三甲基壳聚糖对更昔洛韦凝胶体外促渗作用的考察  

Study on the Transdermal Permeation Enhancement of N-trimenthyl Chitosan on Ganciclovir Gels in Vitro

作　　者：刘新云[1] 甘春英[1] 杨金霞[1] 狄伟[1] 陈兰[2] 

机构地区：[1]湖北医药学院附属太和医院药学部,湖北十堰442000 [2]湖北医药学院药检学院2004级,湖北十堰442000

出　　处：《医药导报》2011年第3期289-291,共3页Herald of Medicine

摘　　要：目的考察N-三甲基壳聚糖(TMC60)对更昔洛韦的体外促渗作用。方法制备含1%TMC60的更昔洛韦凝胶,用Franz扩散池进行体外促渗作用研究,以稳态透皮速率(J)为指标,与同浓度的氮酮、壳聚糖(CS)进行比较。结果空白组、氮酮组、TMC60组及CS组的J值分别为3.822 1,4.098 4,4.205 5及4.356 9μg.(cm2)-1.h-1。与空白组相比,TMC60有显著的促进更昔洛韦体外经皮渗透作用(P<0.05),与同浓度氮酮、CS相比,促渗作用差异无统计学意义(P>0.05)。结论 TMC60可显著促进更昔洛韦的体外经皮渗透。Objective To study the cutaneous absorption enhancement of N-trimethyl chitosan（TMC60） on ganciclovir gel. Methods The ganciclovir gel with 1% TMC60 as absorption enhancer was prepared.The enhancement of TMC60 was studied by using Franz diffusion cells in vitro and stability penetration rate[J,μg·（cm2）-1·h-1] as indicator,in comparison to the same concentration of azone and chitosan（CS）. Results J values of ganciclovir gels without or with azone,TMC60 and CS as enhancer was 3.822 1,4.098 4,4.205 5 and 4.356 9 μg·（cm2）-1·h-1,respectively.Compared with the blank group,TMC60 significantly enhanced transdermal permeation of ganciclovir（P0.05）.While no significant difference was found compared with azone and CS（P0.05）. Conclusion TMC60 could enhance cutaneous absorption of ganciclovir.

关 键 词：N-三甲基壳聚糖 更昔洛韦 凝胶 透皮吸收促进剂 

分 类 号：R978.7[医药卫生—药品] R965[医药卫生—药学]