虎尾轮根提取物对肾阳虚模型小鼠的影响  

Effects of Uraria Crinita Roots on Kidney-YANG Deficiency Mice Induced by Hydrocortisone

作　　者：王燕燕[1,2] 张锦文[3,2] 郭洁茹[4,2] 唐菲[4,2] 张小琼[4,2] 张勇慧[4,2] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院药剂科,湖北宜昌443003 [2]湖北省天然药物化学与资源评价重点实验室,武汉430030 [3]华中科技大学同济医学院附属同济医院药学部,武汉430030 [4]华中科技大学同济医学院药学院,武汉430030

出　　处：《医药导报》2011年第3期292-294,共3页Herald of Medicine

基　　金：国家自然科学基金资助项目(基金编号:30970297);湖北省自然科学基金资助项目(基金编号:2008CDB237);湖北省卫生厅基金资助项目(基金编号:2008Z-Y41);教育部新世纪优秀人才支持计划(基金编号:NCET-08-0224)

摘　　要：目的探讨虎尾轮根不同提取部位对肾阳虚模型小鼠的影响。方法采用氢化可的松致小鼠肾阳虚模型,对小鼠体征、抗氧化能力、应激能力、睾丸质量进行测定。结果虎尾轮根提取物的总膏、乙酸乙酯部位、正丁醇部位可明显提高小鼠食欲,增加体质量,促进生长发育,增加脾脏、胸腺质量,提高脾脏和胸腺指数,明显减轻肾阳虚小鼠生殖器官萎缩,有明显的抗疲劳作用,可提高小鼠的应激能力。结论虎尾轮根可改善肾阳虚小鼠的生存质量,其乙酸乙酯部位、正丁醇部位是其抗肾阳虚主要的药效部位。Objective To study effects of different extracts from Roots of Uraria crinita on kidney-YANG deficiency mice induced by hydrocortisone. Methods Kidney-YANG deficiency mice were induced by hydrocortisone,effects of different extracts from roots of Uraria crinita were observed by observing physical signs,measuring anti-oxidative stress ability and reproductive organ weights. Results Total ointment,acetic ether extract and n-butanol extract significantly enhanced appetite,increased body weight,promoted growth and development,raised spleen and thymic weight index,prominently alleviated reproductive organs＇ atrophy,obviously eliminated fatigue,and enhanced anti-oxidative stress ability of mice. Conclusion Roots of Uraria crinita can improve the life quality of Kidney-YANG deficiency mice,the acetic ether extract and n-butanol extract are the major active extracts on kidney-YANG deficiency.

关 键 词：虎尾轮根 肾阳虚 药效部位 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]