2009年鲍曼不动杆菌的耐药分析  

Analysis of Antibiotic Resistance among Acinetobacter baumannii Isolated from the Patients in the Year of 2009

作　　者：严伟[1] 王飞[1] 俞建[1] 裘国丽 

机构地区：[1]浙江杭州市第一人民医院药剂科,杭州310006 [2]浙江杭州民生药业有限公司,杭州310011

出　　处：《海峡药学》2011年第2期73-74,共2页Strait Pharmaceutical Journal

摘　　要：目的了解医院2009年临床标本鲍曼不动杆菌分布和耐药情况,指导临床合理用药。方法调查2009年从患者不同标本分离的鲍曼不动杆菌,采用κ-B纸片扩散法对常用的抗菌药物进行耐药状况分析。结果 948株鲍曼不动杆菌主要从痰/咽试子(783株)标本中检出(占82.59%),临床分布以重症监护室检出率最高(占49.83%),其中头孢哌酮/舒巴坦(34.45%)、米诺环素(25.00%)和多粘菌素E(1.61%)的耐药率最低,其他药物的耐药率均>40%;加酶抑制剂的抗菌药物的耐药率相对较低;亚胺培南的敏感度已下降。结论监测鲍曼不动杆菌对常用抗菌药物的耐药率,及时调整治疗方案,有助于有效减少和控制鲍曼不动杆菌引起的医院内感染。OBJECTIVE To investigate drug resistance of Acinetobacter baumannii in our hospital in order to provide evidence to proper use antibacterial drug in clinics.METHODS A.baumannii isolates were collected in the yearof 2009.Antibiotic susceptibility testing was performed by K-B method.RESULTS Among 948 isolates,783（82.59%）came from sputum Oropharyngeal swabs material.The most strains from intensive care unit,accounting for 49.83%.The lowest resistance rates were cefoperazone-sulbactam（34.45%）,tobramycin（25.00%）and polymyxin E（1.61%）.The others were more than 40%.The resistance rates of antibacterials added β-lactamase inhibitors were lower than without β-lactamase inhibitors.The A.baumannii sensitive to imipenem was decreased.CONCLUSION To prevent the A.baumannii infection outbreak,it is very important to monitoring the drug sensitive trial of bacteria and advocate the reasonable medication before beginning treatment of infection by A.baumannii.

关 键 词：鲍曼不动杆菌 耐药性 抗菌药物 

分 类 号：R927.3[医药卫生—药学]