薄荷脑和樟脑对复方苯海拉明乳膏透皮作用的影响  

Effect of menthol and camphor on permeation of compound diphenhydramin cream in vitro

作　　者：刘海乐[1] 周彦彬[1] 孙银香[2] 盛小茜[1] 张杰[1] 郑志难[1] 丁劲松[1] 

机构地区：[1]中南大学药学院,长沙410013 [2]珠海市人民医院,广东珠海519000

出　　处：《中南药学》2011年第2期97-101,共5页Central South Pharmacy

摘　　要：目的研究薄荷脑和樟脑对复方苯海拉明乳膏中盐酸苯海拉明和苯佐卡因透皮作用的影响。方法采用改良Franz直立式扩散池,以离体乳猪皮肤为渗透屏障进行体外透皮扩散试验,以盐酸苯海拉明和苯佐卡因的累积渗透量、稳态流量及皮肤滞留量为指标,考察薄荷脑和樟脑在处方中的透皮调节作用。结果薄荷脑和樟脑对盐酸苯海拉明的累积渗透量、稳态流量及皮肤滞留量均无显著影响(P>0.05);对苯佐卡因的累积渗透量、稳态流量有显著抑制作用(P<0.01),并能提高其12 h皮肤滞留量(P<0.05)。结论薄荷脑和樟脑在复方苯海拉明乳膏中除发挥其药理活性外,还能调节药物的透皮吸收,其对苯佐卡因经皮渗透的抑制及皮肤滞留量的增加可能更有利于复方苯海拉明乳膏发挥局部治疗作用。Objective To determine the effect of menthol and camphor on the permeation of diphenhydramine hydrochloride and benzocaine in compound diphenhydramin cream.Methods The permeation experiments were performed in a modified Franz diffusion cell through porcine skin.The permeability coefficients and the accumulation amounts of diphenhydramine hydrochloride and benzocaine in the receptor fluid and skin were calculated.Results There was no significant difference（P〉0.05）in the permeation and accumulation of diphenhydramine hydrochloride between cream with and without menthol and camphor.Menthol and camphor markedly prevented（P〈0.01）the permeation of benzocaine transporting across the skin and promoted the skin accumulation after 12 h（P〈0.05）.Conclusion Menthol and camphor not only have pharmacological activities but also act as penetration enhancers.Those compounds,which can inhibit the benzocaine permeation transdermally and locally,may be beneficial to the topical treatment of compound diphenhydramin cream in clinical practice.

关 键 词：复方苯海拉明乳膏 薄荷脑 樟脑 透皮作用 苯海拉明 苯佐卡因 

分 类 号：R945[医药卫生—微生物与生化药学]