吡咯硫脲类衍生物的合成与生物活性研究  

Synthesis and Biological Activity of Thiourea Derivatives

作　　者：陈治明[1] 吴坤[1] 

机构地区：[1]贵州师范大学化学与材料学院,贵州贵阳550001

出　　处：《安徽农业科学》2011年第3期1401-1402,共2页Journal of Anhui Agricultural Sciences

基　　金：贵州省自然科学基金(黔科合字[2009]2021)

摘　　要：以N-叔丁氧羰基-2-(氨甲基)吡咯烷为原料,合成了吡咯取代的硫脲类化合物。产物结构经元素分析、1HNMR和13CNMR确证。初步生物活性测试结果表明,目标化合物对小麦赤霉菌、农霉菌均有不同程度的抑制作用;浓度为250 mg/L时,化合物3c对小麦赤霉菌抑制率为54.7%,化合物3e对农杆菌抑制率为66.3%。Taking N-Boc-2-aminomethyl-Pyrrolidine as raw material,thiourea derivatives of possible biological activity were synthesized.Their structures were confirmed by Elemental analysis、1HNMR and 13CNMR spectroscopy.The bioassay results of these compounds showed that they had good inhibition rate against Gibbrella zene and Agrobacterium.When the concentration of the compounds was 250 mg/L,the inhibition rate of compound 3c against Gibbrella zene was 54.7%,and that of 3e against Agrobacterium was 66.3%.

关 键 词：硫脲类化合物 合成 生物活性 

分 类 号：S48[农业科学—农药学]