缺氧和缺氧叠加FeCl_3致大鼠肺动脉高压血管内皮损伤的比较研究  

A comparative study on vascular endothelial injuries in two types of hypoxic pulmonary hypertension in rats

作　　者：彭文鸿[1] 毛宝龄[2] 邹霞英[3] 李于功[1] 

机构地区：[1]解放军306医院呼吸科,北京100101 [2]第三军医大学新桥医院呼吸内科研究所,重庆400037 [3]广州军区广州总医院呼吸中心,广东510010

出　　处：《军医进修学院学报》1999年第3期210-212,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的:本实验观察了单纯缺氧及反映炎症因素影响的缺氧叠加静注三氯化铁(FeCl3)所致缺氧性肺动脉高压模型肺血管内皮细胞损伤的变化及差别。方法:应用肺动脉微飘浮导管技术及电镜技术、细胞分离技术观察MPAP,CEC,NO及MDA等指标。结果:缺氧2周后,血CEC、NO、MDA升高,4周时各值高于2周组。缺氧叠加三氯化铁组各值高于单纯缺氧组(P<0.01)结论:缺氧叠加FeCl3致肺动脉高压血管内皮的损伤重于单纯缺氧组。Objective:To compare the vascular endothelial injuries between two different types of hypoxia and hypoxia with intravenous injection of FeCl 3. Methods:MPAP, CEC, NO, MDA were measured by pulmonary arterial catheter technique, electron microscopic and cell collection techniques. Results:MPAP, CEC, NO, MDA were raised gradually in the hypoxic pulmonary hypertension group ( P <0 01), these in the group of hypoxia with intravenous injection of FeCl 3 were raised markedly ( P <0 01). Conclusion:The vascular endothelial injuries in the type of pulmonary hypertension induced by hypoxia with intravcnous injection of FeCl 3 was more severe than that of simple hypoxic pulmonary hypertension, and the new pulmonary hypertension rat model may reflect the effects of inflammatory process in the pathogenisis of pulmonary hypertension.

关 键 词：血管内皮 缺氧 肺动脉高压 FECL3 

分 类 号：R543.202[医药卫生—心血管疾病]