对抗肌动蛋白单克隆抗体诊断早期心肌梗死的评价  

Evaluation of anti-muscle actin monoclonal antibody HHF35 in the diagnosis of early myocardial infarction

作　　者：胡丙杰[1] 陈玉川[1] 祝家镇[1] 毕启明[1] 成建定[1] 李杰 曾家乐 

机构地区：[1]中山医科大学法医病理学教研室,广东广州510089 [2]东莞市公安局法医室,广东511700

出　　处：《法医学杂志》1999年第3期138-139,共2页Journal of Forensic Medicine

摘　　要：为了探讨抗肌动蛋白单克隆抗体(HHF35)在早期心肌梗死死后诊断的特异性,作者用免疫组织化学S-P法检测梗死心肌和其它非梗死性的直接或间接心肌损害的心肌HHF35染色的变化。结果:梗死心肌均可见不同程度的HHF35缺染,其它非梗死性的直接或间接心肌损害的心肌中,如心脏挫伤、心肌炎、出血性休克、电击死、机械性窒息等,也有不同程度的HHF35缺染。因此用HHF35免疫组织化学方法诊断早期心肌梗死需慎重。In order to explore the specificity of anti-muscle actin monoclonal antibody HHF35 in the postmortem diagnosis of early myocardial infarction, the changes of HHF35 staining in the infarcted myocardia and other non-infarcted myocardia with direct or indirect myocar- dial injury were studied with immunohistochemical S-P method. The results showed that the loss of HHF35 staining of different degrees was found in the infarcted myocardia, but also in the other non-infarcted myocardia with direct or indirect myocardial injury, such as cardiac contusion, myocarditis, hemorrhagic shock, electrocution, mechanical asphyxia. So it should be cautious in diagnosing early myocardial infarction with HHF35 immunohistochemisrty.

关 键 词：早期 心肌梗死 肌动蛋白 单克隆抗体 诊断 

分 类 号：D919.4[医药卫生—法医学] R542.220.4[政治法律—法学]