尿Ⅳ-C、CERP、NAG在糖尿病肾病早期诊断中的意义  

Significance of detection urine Ⅳ-C,CERP and NAG in the diagnostic potential of DN

作　　者：孙凤娟[1] 李先伦[2] 刘月平[3] 刘亚平[1] 

机构地区：[1]济宁市第一人民医院内分泌科,山东济宁272111 [2]嘉祥县中医院内科,山东济宁272400 [3]济宁市第一人民医院急诊科,山东济宁272111

出　　处：《中国医药导报》2011年第7期77-78,80,共3页China Medical Herald

摘　　要：目的:探讨尿Ⅳ-C、CERP、NAG在糖尿病肾病(DN)早期诊断中的意义。方法:测量60例糖尿病患者尿微量白蛋白正常38例(DM-1组)、升高22例(DM-2组)和20例正常人的Ⅳ型胶原(Ⅳ-C)、铜蓝蛋白(CERP)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)水平,并分析其与血糖、血肌酐、尿素氮等指标的相关性。结果:病例组尿Ⅳ-C、CERP和NAG均显著高于正常对照组,DM-2组与DM-1组间差异具有统计学意义(P<0.01或P<0.05),且与UAER呈显著正相关;尿微量蛋白升高,与血尿素氮、肌酐等呈正相关;联合检测阳性率显著高于单项检测。结论:尿Ⅳ-C、CERP、NAG作为DM患者早期肾脏损伤的敏感指标优于尿微量蛋白,其升高反映肾脏损害程度,联合检测对预测DM早期肾脏损害的发生和进展具有重要意义。Objective： To investigate the significance of detection urine IV-C.CERP and NAG in the diagnostic potential of （diabetic nephropathy, DN）. Methods： We detected the levels of urine IV-C, CERP and NAG in 60 patients with DM and compared with 20 non-diabetics as control. The diabetic patients were subgrouped into 38 DM-1 subjects whose uri- nary microalbumins were normal, and 22 DM-2 subjects who were with microalbuminuria. And correlation analysis were applied to analyze the relationship between urine IV-C, CERP,NAG and fasting plasma glucose, serum creatinine, blood urea nitrogen. Results： Compared with normal control group, the levels of urine IV-C, CERP and NAG in DM-1 and DM- 2 markedly increased, which also markedly increased in DM-2 compared with DM-1 （P〈0.01 or P〈0.05）. Urine IV-C, CERP and NAG in DM showed a positive correlation with UAER. Urine CERP in DM showed a significantly positive cor- relation with BUN, Cr, and Urine NAG in DM showed a significantly positive correlation with Cr. The positive rate of the combining examination of Urine IV-C, CERP and NAG was markedly higher than single examination. Conclusion： Urine IV-C, CERP and NAG as sensitive indexes in early kidney lesion were superior to UAER, and the combining examination of Urine IV-C, CERP and NAG has great significance to forecast the development of early kidney lesion.

关 键 词：糖尿病肾病 尿铜蓝蛋白 尿Ⅳ型胶原蛋白 尿N-乙酰-Β-D-氨基葡萄糖苷酶 

分 类 号：R587.2[医药卫生—内分泌]