薄荷油-β-环糊精聚合物微球包合物的制备与表征  

Preparation and characterization of peppermint oil-β-cyclodextrin polymer microsphere inclusion compound

作　　者：李仲谨[1] 杨威[1] 陈玉苗[1] 丁金皓[1] 韩春鹏[1] 

机构地区：[1]陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西西安710021

出　　处：《中草药》2011年第2期271-274,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(50573046);陕西科技大学研究生创新基金资助

摘　　要：目的优选薄荷油β-环糊精聚合物(β-CDP)微球包合的最佳工艺。方法采用饱和水溶液法制备薄荷油β-CDP微球包合物,通过L9(34)正交试验设计以回归分析法为指标对制备工艺进行了优化;分别用红外光谱、综合热分析和X射线衍射分析法对薄荷油β-CDP微球包合物进行表征。结果最佳制备工艺条件是选定A2B2C1D3;影响因素的大小依次为:β-CDP微球和与水之比>β-CDP微球和薄荷挥发油投料比>包合温度>包合时间;IR、XRD、TGA等方法证明了包合物的生成。结论薄荷油的包合方法合理可行。Objective To optimize the including preparation for peppermint oil-β-cyclodextrin polymer（β-CDP） microsphere inclusion compound.Methods Peppermint oil-β-CDP microsphere inclusion compound was prepared by using co-precipitation.The preparation process was optimized through the L9（34） orthogonal test design and regression analysis.Peppermint oil-β-CDP microsphere inclusion compound was characterized by infrared（IR） spectroscopy,thermogravimetric analysis（TGA）,and X-ray diffraction（XRD）.Results The best technological condition was A2B2C1D3,and the order of the influence factors was the proportion of β-CDP microsphere and water the percentage of peppermint oil in β-CDP microsphere inclusion temperature inclusion time.The formation of peppermint oil β-CDP microspheres inclusion compound was proved by the results of IR,XRD,TGA analyses.Conclusion The method is reasonable and feasible.

关 键 词：薄荷油 β-环糊精聚合物微球 红外光谱 X衍射 热重分析 

分 类 号：R286.02[医药卫生—中药学]