转化生长因子-β参与CD4^＋CD25^＋调节性T细胞诱导的发育研究进展  

Research advances of TGF-β to the induction of CD^＋ CD25^＋ regulatory T cells

作　　者：张伯彬[1] 尹辉[2] 古宏标[1] 

机构地区：[1]广东药学院病理生理学教研室,广州510006 [2]广东药学院微生物与免疫学教研室,广州510006

出　　处：《国际免疫学杂志》2011年第2期139-142,共4页International Journal of Immunology

摘　　要：CD4^＋CD25^＋调节性T细胞（CD4^＋CD25^＋Treg）足一类具有免疫调节功能的淋巴细胞，在维持机体免疫耐受和免疫应答稳态方面发挥重要作用。转化生长因子β（TGF—β）与CD4^＋CD25^＋Treg的发育分化和功能有着密不可分的关系，虽然作用机理尚不完全明了，但其重要性毋情置疑。CD4^＋ CD25^＋ regulatory T cells （ CD4^＋ CD25^＋ Treg） are a type of T lymphocytes that function in immune regulation and play a major role in maintaining the homeostasis of immune tolerance and immune response. Transforming growth factor β （TGF-β）, an important cytokine, plays a critical role in the development, differentiation and function of Treg. However,tile exact mechanism throught which TGF-β funcitions has not been completely understood. The role and influencing factors of TGF-β to the development arid differentiation of Tree are summarized in this review.

关 键 词：TGF—β FOXP3 CD4^+CD25^+调节性T细胞 诱导 

分 类 号：R3[医药卫生—基础医学]