柞蚕蛹虫草多糖对酒精／四氯化碳复合因素所致肝损伤保护作用的研究  

Studies on the protective effect of CMPS on alcohol/CCL4 to liver injury

作　　者：黄晓巍[1] 卢彤宇[2] 张永和[1] 

机构地区：[1]吉林省长春中医药大学附属医院实验研究中心,130021 [2]吉林省人民医院药剂科

出　　处：《国际中医中药杂志》2011年第3期209-211,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的 观察柞蚕蛹虫草多糖（CMPS）对酒精／四氯化碳（CCL4）复合因素所致肝损伤的保护作用。方法采用酒精／CCL。复合因素复制肝损伤模型，通过全自动牛化分析仪测定天门冬氨酸氨基转换酶（AST）、丙氨酸氯基转换酶（ALT）、碱性磷酸酶（ALP）、总胆固醇（T-CHO）、总蛋白（TP）、白蛋白（ALB）等指标。分光光度法测定：超氧化物歧化酶（SOD）、丙二醛（MDA）含量。结果CMPS可降低模型动物血清AST、ALT、ALP、MDA的含量，提高血清ALB、SOD的含量。结论CMPS对肝损伤有一定保护作用，其作用机制可能与CMPS保护细胞膜、抗氧化等机制有关。Objective To study the protective effect of CMPS on alcohol/ CCL4 to liver injury. Methods Alcohol/CCL4 were given to rats to establish models of liver injury rats. The contents of AST, ALT, ALP, T-CHO, T-BIL, TP, ALB and A/G were determined by biochemical analyzer. The contents of SOD and MDA were by spectrophotometry. Results CMPS could reduce the levels of AST, ALT, ALP and MDA and raise the levels of ALB and SOD in mice model. Conclusion CMPS could protect liver injury. The mechanism may be related with its protection of cell membrane and antioxygen.

关 键 词：柞蚕蛹虫草多糖 酒精/四氯化碳复合因素 肝损伤 

分 类 号：R285.5[医药卫生—中药学]