妊娠期高血压疾病合并死胎应用米索前列醇引产效果分析  

Effect of Misoprostol on gestational hypertension with induction of labor stillbirth

作　　者：陈旭军[1] 

机构地区：[1]成都市第七人民医院妇产科,四川成都610021

出　　处：《实用医院临床杂志》2011年第2期130-131,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨米索前列醇用于妊娠期高血压疾病合并死胎引产的效果及安全性。方法 2004年1月至2008年9月在东帝汶国家医院因妊娠期高血压疾病合并死胎引产术的孕妇60例,其中米索前列醇引产30例(阴道后穹窿给予米索前列醇25μg,如果没有规律宫缩6小时后重复一次,最多4次),催产素引产30例(催产素2.5单位+5%葡萄糖液体500 ml,每分钟10滴开始,如果没有规律宫缩每30分钟增加10滴,直到有正规宫缩)。分析比较两种引产方式的产程、引产成功率、产后出血量。结果米索前列醇和催产素在引产产程、产后出血量方面差异均有统计学意义(P<0.01,P<0.05),而引产成功率差异无统计学意义(P>0.05)。结论米索前列醇用于妊娠期高血压疾病合并死胎引产可以明显缩短产程,减少产后出血量,引产成功率高,无子宫破裂,无孕产妇死亡,是安全有效的。Objective To determine the efficacy and safety of Misoprostol on gestational hypertension with induction of labor stillbirth.Methods Sixty cases of gestational hypertension with induction of labor stillbirth in Dili National hospital from Jan 2004 to Sept 2008 underwent indication of labor stillbirth were divided into two groups averagely.For the Misoprostol group,25ug of Misoprostol was inserted into the posterior vagial fornix every 6 hours a time（4 times at most）.For the oxytocin group,we infused oxytocin（2.5 units of oxytocin ＋ 500ml of 5% glucose solution,10 drops per minute）and increased the infusion rate by 10 drops per minute every 30 minutes.Then we observed the birth process,success rate of labor induction and postpartum hemorrhage of the two groups.Results Birth process of the Misoprostol group was significantly shorter than that of the oxytocin group（P0.01）.There was no significant difference in success rate of labor induction between the two groups（P0.05）.There was significant difference in postpartum hemorrhage between the two groups（P0.05）.Conclusion Misoprostol can be used for gestational hypertension with induction of labor stillbirth.Ii is an efficient and safe method with high success rate of labor induction,no uterine rupture and no maternal deaths,which may obviously shorten birth process and reduce postpartum hemorrhage.

关 键 词：妊高征 米索前列醇 催产素 死胎引产 

分 类 号：R719.3[医药卫生—妇产科学] R714.246[医药卫生—临床医学]