布地奈德福莫特罗粉吸入剂对中度支气管哮喘患儿小呼吸道功能的影响  

Effect of Budesonide Formoterol Fumarate Powder for Inhalation on Small Airway Function in Children with Moderate Asthma

作　　者：吴庆莉[1] 林荣军[2] 路玲[2] 

机构地区：[1]兖州市人民医院儿科,山东兖州272100 [2]青岛大学医学院附属医院儿科,山东青岛266003

出　　处：《实用儿科临床杂志》2011年第4期265-266,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的观察布地奈德福莫特罗粉吸入剂治疗儿童中度支气管哮喘的疗效和不良反应及对小呼吸道功能的影响。方法选取青岛大学医学院附属医院哮喘专家门诊初诊的中度支气管哮喘患儿40例,病例均未接受过正规吸入激素治疗。入院后给予布地奈德福莫特罗粉吸入剂,每次1吸,每天2次,治疗12周。分别在治疗4周、8周、12周进行哮喘控制水平(控制、部分控制、未控制)评估,同时测定其肺功能,包括一秒钟用力呼气量(FEV1)占预计值百分比、最大呼气流量(PEF)占预计值百分比、25%用力呼气肺活量(FEF25)、50%用力呼气肺活量(FEF50)、75%用力呼气肺活量(FEF75),并观察不良反应发生情况。对治疗前后肺功能结果进行比较,同时进行病情评估。结果 1.临床控制率:治疗12周,临床控制36例(90%),部分控制4例(10%),总有效率为100%。2.肺功能改善情况:在治疗4周,FEV1、PEF、FEF25、FEF50、FEF75均有显著改善,且在12周的随访过程中,上述指标得到持续改善。治疗12周FEF75、FEF50、FEF25均恢复到正常水平。结论布地奈德福莫特罗粉吸入剂治疗儿童中度支气管哮喘,对缓解症状和改善肺功能均有良好效果,尤其可有效改善哮喘患儿小呼吸道功能,从而达到哮喘临床控制或部分控制,且不良反应发生率低。Objective To observe the clinical efficacy and adverse reactions of budesonide formoterol fumarate powder for inhalation treatment in children with moderate asthma,and its effect on small airway function.Methods Forty children with moderate asthma were selected,who were doctored for the first time in asthma clinic of the Affiliated Hospital of Qingdao University Medical College.All the cases had not received formal inhaled corticosteroid before treatment,and were given budesonide formoterol fumarate powder for inhalation,inhaling once each time,twice a day,for a total of 12 weeks.After the treatment for 4 weeks,8 weeks and 12 weeks,respectively,the regulated levels of asthma were assessed,the occurrence of adverse events were observed and the pulmonary function were determined,including forced expiratory volume in one second（FEV1）,peak expiratory flow（PEF）,forced expiratory flow after 25% of the forced vital capacity had been exhaled（FEF25）,forced expiratory flow after 50% of the forced vital capacity had been exhaled（FEF50） and forced expiratory flow after 75% of the forced vital capacity had been exhaled（FEF75）.Lung function indexes before and after treatment were compared,at the same time,and the patients conditions′ were estimated.Results 1.Clinical control rate indicated that after 12 weeks of treatment,36 children were clinically controlled（90%）,4 children were partially controlled（10%）,total effective rate was 100%.2.Improvement of pulmonary function：in the first 4 weeks after treatment,pulmonary function indexes were significantly improved,and at 12 weeks of follow-up process,these indexes were continuing to improve.After treatment for 12 weeks,FEF75,FEF50,FEF25 individually were increased to normal levels.Conclusions Budesonide formoterol fumarate powder for inhalation in treatment of children with moderate asthma have good effect on alleviating symptoms and improving lung function,particularly improving small airway functions of asthmatic children,allowing them achieve as

关 键 词：布地奈德福莫特罗粉吸入剂 哮喘 小呼吸道 肺功能 儿童 

分 类 号：R725.6[医药卫生—儿科]