外排泵抑制剂对铜绿假单胞菌碳青霉烯类抗菌药物敏感性的影响  

Effects of efflux pump inhibitors on carbapenems in pseudomonas aeruginosa

作　　者：刘永芳[1] 张浩[2] 周云[3] 凌保东[3] 陈金文[4] 霍亚平[4] 

机构地区：[1]川北医学院附属医院感染科,四川南充637000 [2]川北医学院附属医院皮肤科,四川南充637000 [3]川北医学院药物研究所,四川南充637000 [4]川北医学院附属医院微生物室,四川南充637000

出　　处：《中华医院感染学杂志》2011年第5期841-843,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解不同外排泵抑制剂(EPIs)在铜绿假单胞菌(PAE)对碳青霉烯类抗菌药物敏感性的影响。方法用琼脂对倍稀释法检测联合两种EPIs前后亚胺培南(IMP)、美罗培南(MER)的MIC值。结果 PAβN浓度为40μg/ml时能明显增强IMP、MER对PAE的敏感性;IMP、MER的敏感率分别由22.45%→77.55%,75.5ORP1%→91.84%;统计分析显示,差异有统计学意义(P<0.05);奥美拉唑(OMP)20μg/ml对碳青霉烯类抗菌药物敏感性影响较小。结论适当浓度的EPIs能增强碳青霉烯类抗菌药物对PAE的敏感性。OBJECTIVE To study the effect of efflux pump inhibitors on carbapenems in Pseudornonas aeruginosa clinical isolates. METHODS The MICs of imipenem and meropenem with or without efflux pump inhibitors （EPIs） against 49 isolates were determined by the agar dilution method. RESULTS At a concentration of 40μg/ml, PAI3N had obviously effects on carbapenems MICs. The rate of sensitivity of imipenem and meropenem increased from 22.45% to 77.55% and from 75.51% to 91.84%. Statistical analysis showed there were statistical significance （P〈0.05）. Omeprazole at a concentration of 20μg/ml had fewer effects on carbapenems MICs. CONCLUSION EPIs at a suitable concentration can increase the sensitirity of carbapenems in P. aeruginosa clinical isolates.

关 键 词：铜绿假单胞菌 耐药 奥美拉唑 泵抑制剂 碳青霉烯类抗菌药物 

分 类 号：R378[医药卫生—病原生物学]