联合应用氯霉素、头孢唑肟及甲硝唑治疗颅脑创伤后颅内感染  

Chloramphenicol combined with ceftizoxime and metronidazole on treatment of patients with intracranial infection after craniocerebral trauma

作　　者：龙连圣[1] 刘桂玲[2] 王伟明[1] 辛志成[1] 赵朝晖[1] 李夏良[1] 张建忠[1] 蒋超超[1] 苏强[1] 章红梅[1] 

机构地区：[1]解放军第98医院脑外二科,浙江湖州313000 [2]解放军第98医院院感科,浙江湖州313000

出　　处：《中华医院感染学杂志》2011年第5期964-966,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨联合应用氯霉素、头孢唑肟及甲硝唑治疗颅脑创伤后颅内感染的疗效。方法自2007年1月起医院对确诊颅脑创伤后颅内感染而细菌学检查阴性的患者常规联合应用氯霉素、头孢唑肟及甲硝唑,分析其临床资料及疗效。结果 2007年1月-2009年8月医院共收治颅脑创伤患者3537例,并发颅内感染54例,脑脊液细菌培养阴性52例,均联合应用氯霉素、头孢唑肟及甲硝唑治疗,颅内感染均得到有效控制。结论联合应用氯霉素、头孢唑肟及甲硝唑是治疗颅脑创伤后颅内感染的有效方案。OBJECTIVE To study the curative effect of chloramphenicol combined with ceftizoxime and metronidazole on the patients with intracranial infection after craniocerebral trauma. METHODS The relevant clinical data of cases of patients with intracranial infection after craniocerebral trauma, treated with of chloramphenicol combined with ceftizoxime and metronidazole was analyzed and summarized in hospital from Jan 2007 to Aug 2009. RESULTS In 3537 cases of craniocerebral trauma,54 cases were complicated with intracranial infection. 32 cases were treated only by intravenous administration antibiotics. Besides intravenous administration, 22 cases were managed by continual drainage through lumbar subarachnoid. The intracranial infection in all of 54 patients were effectively controlled. No patient died of intracranial infection. CONCLUSION Chloramphenicol combined with ceftizoxime and metronidazole in treating intracranial infection after craniocerehral trauma is effective and safe.

关 键 词：颅内感染 颅脑创伤 氯霉素 头孢唑肟 甲硝唑 

分 类 号：R978.1[医药卫生—药品]