3年医院感染病原菌耐药性监测分析  

Drug resistance of pathogens causing nosocomial infection in 3 years:a monitoring analysis

作　　者：王蕾[1] 李亚征[1] 

机构地区：[1]北京电力医院感染管理科,北京100073

出　　处：《中华医院感染学杂志》2011年第5期972-974,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解医院感染病原菌耐药情况。方法对2007-2009年全部医院感染病例中分离出的病原菌的耐药性进行统计分析。结果革兰阴性菌占64.4%,革兰阳性菌占24.6%,真菌占11.0%;病原菌居检出首位的是铜绿假单胞菌149株,占16.0%,其对亚胺培南耐药率为38.9%,检出第2位的为大肠埃希菌121株,占13.0%,产ESBLs菌株检出率和对喹诺酮类抗菌药物耐药率逐年增高,金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌检出率为73.3%,屎肠球菌对大部分所监测抗菌药物均显示高耐药性,耐万古霉素肠球菌检出率为5.2%。结论医院感染病原菌耐药性明显,加强耐药性监测,合理使用抗菌药物,提高医务人员手卫生的依从性,是减缓耐药菌产生和传播的重要手段。OBJECTIVE To investigate the drug resistance of nosocomial infection pathogens. METHODS The analysis of drug resistant pathogens isolated from all hospital infections from 2007 to 2009 was carried out. RESULTS The Gram-negative bacteria accounted for 64. 4%, and the Gram-positive bacteria accounted for 24.6%, and the fungi accounted for 11. 0%. The first place in the detection rate of Pseudomonas aeruginosa resistant to imipenem was close to 16.0% （149 strains）, and the second place of the detection rate of the ESBLs- producing Escherichia coli was 13.0% （121 strains） and the detection resistance rate of quinolone increased year by year. The detection rate of MRSA was 73. 3%. Enterococcus faecium has shown high resistance to the majority of monitored antimicrobial agents. The detection rate of VRE was 5. 2%. CONCLUSION The drug resistance of hospital infection pathogens is significant. Some important means to slow down the emergence and spread of drug resistant should be adopted, such as strengthening the monitoring of drug resistance, rational use of antimicrobial agents and improving the hand hygiene compliance of the medical staff.

关 键 词：医院感染 病原菌 耐药性 抗菌药物 

分 类 号：R378[医药卫生—病原生物学]