临床分离主要革兰阴性杆菌分布及耐药性监测  

Distribution and drug resistance of main gram-negative bacilli isolated from clinics

作　　者：陈梅莉[1] 马友正[1] 

机构地区：[1]绍兴市人民医院药剂科,浙江绍兴312000

出　　处：《中华医院感染学杂志》2011年第5期986-988,共3页Chinese Journal of Nosocomiology

摘　　要：目的调查2009年医院临床分离主要革兰阴性杆菌的样本分布和耐药性,为临床医师合理用药提供参考。方法收集临床分离革兰阴性杆菌培养鉴定,采用纸片扩散法(K-B法)测定14种抗菌药物的敏感情况,用WHONET 5软件进行分析。结果 2009年共分离出革兰阴性菌1322株,前4位的是大肠埃希菌431株(32.60%),产超广谱β-内酰胺酶(ESBLs)率为47.56%;肺炎克雷伯菌266株(20.12%),产ESBLs发生率为30.45%;鲍氏不动杆菌224株(16.94%);铜绿假单胞菌140株(10.59%);主要革兰阴性杆菌对所有抗菌药物均产生一定的耐药性。结论医院感染的耐药性十分严重,医院应加强监测与控制;临床医师应在经验用药前关注目前细菌的耐药情况正确选用抗菌药物。OBJECTIVE To investigate the distribution and antibiotic resistance of the main Gram-negative bacillus isolated from our hospital in 2009 and offer suggestions for clinic. METHODS Gram-negative bacilli were cultured by routine methods. The antibiotic susceptibilities to 14 kinds of antibiotics were tested By K-B method and analyzed by Whonet software. RESULTS There were 1322 G- Bacillus isolated from Clinical specimens and the top four of them were 431 Escherichia coli （E. coli）, 266 Klebsiella pneumoniae （KPN）, 224 Acinetobacter baumannii（ABA）, 140 Pseudomonas aeruginosa （PAE）. The detection rate of ESBLs-producing E. coli was 47. 56 and that of KPN was 30.45%. The resistance 14 kinds of antibiotics to were in varying degrees in the four bacilli. CONCLUSIONS Drug resistance status of pathogens in nosocomial infections to antibiotics is very serious. The monitoring and controlling should be strengthened. Clinicians should rationally choose antibiotics before experimental medication according to the drug resistance of the bacillus.

关 键 词：医院感染 革兰阴性杆菌 抗菌药物 耐药性监测 

分 类 号：R378[医药卫生—病原生物学]