2007-2009年鲍氏不动杆菌的耐药动态分析  

Antibiotic resistance of acinetobacter baumannii isolated from 2007 to 2009:a dynamic analysis

作　　者：王飞[1] 俞建[1] 严伟[1] 

机构地区：[1]杭州市第一人民医院药剂科,浙江杭州310006

出　　处：《中华医院感染学杂志》2011年第5期1007-1009,共3页Chinese Journal of Nosocomiology

摘　　要：目的监测医院临床标本鲍氏不动杆菌的耐药情况,指导临床合理用药。方法回顾性调查2007-2009年从患者不同标本分离的鲍氏不动杆菌,采用K-B纸片扩散法对常用的抗菌药物进行耐药动态分析。结果鲍氏不动杆菌3年检出率分别为4.86%、4.98%、5.12%;对常用抗菌药物的耐药率总体呈上升趋势,其中头孢哌酮/舒巴坦和妥布霉素的耐药率最低,3年来均保持<50.00%,其他药物的耐药率均有>50.00%的现象;头孢曲松、环丙沙星、头孢哌酮/舒巴坦的耐药率上升最快;加酶抑制剂的抗菌药物的耐药率相对较低;亚胺培南的敏感度已下降。结论动态监测鲍氏不动杆菌的耐药谱变化,及时调整治疗方案,有助于有效减少和控制鲍氏不动杆菌引起的医院感染。OBJECTIVE To monitor drug resistance of Acinetobacter baurnannii in hospital from 2007 to 2009 in order to provide evidence to proper use antibacterial drug in clinics. METHODS A. baumannii isolates were collected from 2007 to 2009. Antibiotic susceptibility testing was performed by K-B method. RESULTS The isolating rate of A. baumannii from 2007 to 2009 was 4. 86%,4. 98% and 5. 12%, respectively. There was a elevated tendency of the resistance rates to common antibacterials in A. baumannii during the past3a. The resistance rates of A. baumannii to cefoperazone-sulbactam and tobramycin were less than 50%, the others were more than 50.00 %. The increasing resistance rates of ceftriaxone, ciprofloxacin cefoperazone sulbactam were very quickly. The resistance rates of antibacterials added β-lactamase inhibitors were lower than that without β- lactamase inhibitors. The sensitivity of A. baumannii to imipenem was decreased. CONCLUSION To prevent the A. baumannii infection outbreak,it is very important to monitor the drug sensitive test of bacteria and advocate the reasonable medication before beginning the treatment of infection caused by A. baumannii.

关 键 词：鲍氏不动杆菌 耐药性 抗菌药物 

分 类 号：R378[医药卫生—病原生物学]