北京市≥15岁常住人口麻疹抗体水平研究  

Analysis of Measles Antibody Level in Persistent Population Aged ≥15 Years Old in Beijing

作　　者：刘东磊[1] 孙美平[1] 卢莉[1] 王冬梅[2] 刘芳[3] 徐若辉[4] 宁召起[5] 张曙光 庞星火[1] 

机构地区：[1]北京市疾病预防控制中心,北京100013 [2]北京市宣武区疾病预防控制中心,北京100053 [3]北京市朝阳区疾病预防控制中心,北京100026 [4]北京市海淀区疾病预防控制中心,北京100037 [5]北京市通州区疾病预防控制中心,北京101100 [6]延庆县疾病预防控制中心,北京延庆102100

出　　处：《中国疫苗和免疫》2011年第1期16-21,共6页Chinese Journal of Vaccines and Immunization

基　　金：北京市科学技术委员会项目(Z0005190043811);北京市优秀人才培养资助项目(2006WS-18)

摘　　要：目的了解北京市≥15岁常住人口麻疹抗体水平和影响因素,评价成人麻疹易感性。方法采用分层多级整群抽样的方法,按照城区、近郊、远郊分层选择调查对象,收集个人基本信息、麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)接种史、患病史等信息,使用酶联免疫吸附试验检测麻疹IgG抗体。结果北京市≥15岁常住人口麻疹抗体阳性率为92.83%;多因素分析显示,居住的地理位置、年龄、患病史均对抗体水平有影响。结论北京市≥15岁常住人口麻疹抗体阳性率较高,不会发生大范围的爆发或流行,但成人活动范围广,作为传染源的意义重大,从消除麻疹的要求考虑,仍有必要对成人接种MV。Objective To explore the measles antibody level and among the population ≥15 years old and the influence factors in Beijing,so as to eraluate the sasceptability of adult to the Measles.Methods Using multi-cluster sampling to select the objects from downtown,suburban and rural areas.Private information,history of vaccination and illness were collected.IgG antibody was measured by ELISA assay in Beijing CDC.Result The seropositive rate≥15 years old was 92.83%.In multivariate analysis model,the site of living location,age,and history of illness were main influence factors to the antibody level using multiple regression analysis.Conclusion The seropositive rate among the population ≥15 years old was high enough to prevent outbreak and epidemic of measles.Adult measles cases are main resources for measles transmission.Vaccination for adult is a key measure to eliminate measles.

关 键 词：麻疹 抗体水平 人群免疫力 

分 类 号：R511.1[医药卫生—内科学] R186[医药卫生—临床医学]