儿童接种进口甲型肝炎灭活疫苗10年后抗体持久性观察  被引量:2

Immunogenicity Duration Analysis of Hepatitis A Inactivated Vaccine for 10 Years after Primary Vaccination in Children

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作  者:边国林[1] 董红军[1] 马瑞[1] 倪红霞[1] 周绍英[1] 胡逢蛟[1] 林永兴[1] 许国章[1] 

机构地区:[1]宁波市疾病预防控制中心,浙江宁波315010

出  处:《中国疫苗和免疫》2011年第1期38-40,共3页Chinese Journal of Vaccines and Immunization

摘  要:目的监测儿童接种进口甲型肝炎(甲肝)灭活疫苗(Hepatitis A Inactivated Vaccine,HepA-I)10年后,抗甲肝病毒抗体[Antibody to Hepatitis A Virus(HAV),Anti-HAV]的阳性[≥5毫国际单位/毫升(mIU/ml)]率和几何平均浓度(Geometric Mean Concentration,GMC)。方法对平均年龄2岁的116名儿童,按0、6个月免疫程序接种HepA-I,免疫后1个月采集静脉血标本,检测Anti-HAV,并对110名免疫后Anti-HAV阳性的儿童随访10年后,采集静脉血标本定量检测Anti-HAV。结果免疫后1个月Anti-HAV阳性率100%,至10年后Anti-HAV阳性率99.09%,GMC为61.59mIU/ml。结论进口儿童剂型HepA-I具有良好的免疫持久性。Objective To observe anti-HAV positive rate and geometric mean concentration 10 years after primary vaccination of a hepatitis A inactivated vaccine in children.Methods 116 children of average 2 years old who were inoculated with hepatitis A inactivated vaccine by 0 and 6 month were selected to test the blood samples at l month after primary vaccination for anti-HAV.Among them,110 children who succeeded with serum conversion were investigated on serum anti-HAV level in quantitative assay at 10 years after primary vaccination.Results Anti-HAV positive rate was as high as 100% at 1 month after primary vaccination.Serum positive rate still remains at 99.09%,and GMC reaches to 61.59 mIU/ml even 10 years after primary vaccination.Conclusion Imported hepatitis A inactivated vaccine for children has satisfied persistent immunogenicity.

关 键 词:预防接种 甲型肝炎灭活疫苗 抗甲型肝炎病毒抗体 免疫持久性 

分 类 号:R186[医药卫生—流行病学] R512.61[医药卫生—公共卫生与预防医学]

 

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