长春地区2008年婴幼儿轮状病毒腹泻临床与病原学研究  

Study of Etiology and Clinical Data for Infants with Rotavirus Diarrhea in Changchun Province in 2008

作　　者：张晓杰[1] 李丽红[1] 孙利伟[1] 王承训[1] 黎伟明[2] 杨显达[2] 刘愉[1] 赵艳玲[1] 邓琳菲[1] 贺岩[1] 田玉玲[1] 

机构地区：[1]长春市儿童医院,吉林长春130051 [2]吉林省疾病预防控制中心,长春130062

出　　处：《中国疫苗和免疫》2011年第1期59-61,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解长春地区2008年婴幼儿轮状病毒(Rotavirus,RV)腹泻临床及病原情况。方法用聚丙烯凝胶电泳和/或酶联免疫吸附试验及逆转录-聚合酶链反应,对2008年长春市儿童医院因腹泻住院婴幼儿粪便标本441份进行检测,并对临床资料进行分析。结果婴幼儿腹泻RV检出率53.29%;人(Human)RV(HRV)感染有3月和11月两个高峰。基因型分布:G分型,流行优势型为G(340.85%),其次为G(112.34%),然后是G2、G(96.81%),G4、G8、G11、G13、G14、G15、G1(80.43%),未分型27.66%;P分型,流行优势型为P(845.11%),P(417.02%),P(61.70%),P1(01.28%),P9、P1(10.43%),未分型34.04%;HRV感染平均月龄为(11.07±6.73),97.36%发生于≤24月龄儿童;HRV感染男、女性别比为1.87:1;临床表现发热占43.83%(103/235),呕吐占50.64%(119/235),神经系统症状占1.28%(3/235),呼吸道症状占42.13%(99/235),平均住院(5.13±2.09)d。结论 HRV是2008年长春地区婴幼儿病毒性腹泻的主要病原;HRV流行株呈现超常多样性;HRV腹泻常伴有呼吸道症状。Objective To find out the clinical and etiology situation of infants with rotavirus diarrhea in Changchun Area in 2008.Methods 441 stool specimens selected from the in-patients of Changchun Children＇s Hospital were tested by the method of PAGE and/or ELISA and reverse transcriptionpolymerase chain reaction（RT-PCR）in 2008.And the clinical data were studied.Results The detection rate of infant diarrhea caused from rotavirus was 53.29%.March and October are the 2 peaks of rotavirus infection in 2008.Distribution of G genotype shows that epidemic type in Changchun was G3 type（40.85%）,followed by it was the G1 type（12.34%）,then G2、G（96.81%）、G4、G8、G11、G13、G14、G15、G18 type（0.43%）,no type was 27.66% in 2008.Distribution of P genotype shows that epidemic type was P8 type（45.11%）,then P（417.02%）,P（61.70%）,P1（01.28%）P8、P1（10.43%）,no type was 34.04% ;The average age of the infants is 11.07±6.73 months.97.36% infants were ≤24 months.Ratio of male and female was 1.87：1.43.83%（103/235）have fever,50.64%（119/235）vomiting,1.28%（3/235）had symptom of nervous system,42.13%（99/235）had respiratory tract symptom,the average day of hospitalization was（5.13±2.09）.Conclusions Rotavirus is the main pathogen of infant diarrhea in Changchun in 2008;Strains of rotavirus have uncommon diversity;Viral diarrhea of rotavirus often accompany with respiratory tract symptom.

关 键 词：婴幼儿腹泻 轮状病毒 

分 类 号：R512.2[医药卫生—内科学]