胃肠间质瘤影响预后的多因素分析  

Prognosis of gastrointestinal stromal tumor:a multivariate analysis

作　　者：冯涛[1] 王云海[2] 许新才[2] 潘金强[1] 

机构地区：[1]新疆医科大学第四附属医院普外二科,新疆乌鲁木齐830000 [2]新疆医科大学第一附属医院胃肠/干外科,新疆乌鲁木齐830000

出　　处：《中国实用外科杂志》2011年第3期238-239,242,共3页Chinese Journal of Practical Surgery

摘　　要：目的探讨胃肠道间质瘤(GIST)的临床特点及影响预后的相关因素。方法 2002年2月至2008年10月新疆医科大学第一、第四附属医院对75例GIST病人的临床病理资料进行回顾性分析。结果胃肠道间质瘤好发于中年,以胃多发,其预后在年龄、性别、族别、术前不适期、术前症状和术前贫血等方面差异无统计学意义(P>0.05);而在肿瘤部位、肿瘤直径、手术方式、术中浸润转移、分期、分级、复发转移方面差异有统计学意义(P<0.05)。多因素分析显示:肿瘤直径、术中浸润转移是影响病人预后的独立影响因素。结论肿瘤直径、术中浸润转移是影响GIST病人预后的重要因素。肿瘤的部位、手术方式、分期、分级、复发转移也是评价预后的指标。手术完整切除依然是有效的治疗方法。Objective To explore the clinical characteristics as prognostic factors in patients with gastrointestinal stromal tumors （GISTs）. Methods The clinical and pathological data of 75 patients with GISTs admitted between February 2002 and October 2008 at the First and Fourth Affiliated Hospital of Xin Jiang Medical University were analyzed retrospectively. All the patients were followed up. COX Proportional Hazard Model was used in multivariate analysis. Results GISTs occurred more frequently in middle-aged patients and most of them were located in the gaster. Age, gender, nationality, preoperative discomfort, preoperative symptoms and preoperative anemia were not statistically different from prognosis （P〉0.05）. The diameter of the tumor, surgery, during the invasion and metastasis, staging, grading, the transfer of recurrence significantly （P〈0.05）. The diameter of the tumor, intraoperative invasion and metastasis were independent prognostic factors affecting prognosis of patients based on a multivariate analysis of COX Proportional Hazard Model. Conclusion Tumor diameter, intraoperative invasion and metastasis are important factors affecting the prognosis of patients with GIST. The tumor sites, operation methods, staging, grading, recurrence and metastasis are also the evaluation indexes of prognosis. Completive surgical excision is still an effective treatment.

关 键 词：胃肠道间质瘤 预后 随访 多因素分析 

分 类 号：R6[医药卫生—外科学]