三齿仲胺配合物的合成、表征及生物活性的研究  

Synthesis,Characterization and Biological Activities Investigation of Tridentate Secondary Amine Complexes

作　　者：戴雪芹[1] 贾春满[1] 张岐[1] 黄韬[1] 胡琴[1] 曹本男[1] 

机构地区：[1]海南大学海南省精细化工重点实验室,海南海口570228

出　　处：《精细化工》2011年第3期260-264,共5页Fine Chemicals

基　　金：海南省自然科学基金(209001);海南大学重点基金(hd09xm07/24)共同资助~~

摘　　要：合成了一种三齿配体N-(4-甲基苯)-N′-(2-(4-甲基苯氨基)乙基)乙烷-1,2-二胺,并制备了它的3种过渡金属配合物[ML(H2O)2Cl]Cl(M=CuⅡ,CoⅡ,NiⅡ),用元素分析、核磁、红外和摩尔电导等表征了配体及其金属配合物的组成和结构。对Ni—L进行了单晶结构解析,配合物为六配位的八面体结构,配体采用三齿配位。利用紫外光谱和荧光光谱法研究了配合物与小牛胸腺DNA的作用方式,结果表明,3种金属配合物可能以静电方式与DNA作用。Cu—L、Ni—L、Co—L3种配合物与DNA的结合常数分别为2.99×104、9.78×103、3.66×103。A novel tridentate ligand（L）,N-（4-methylbenzyl）-N′-[2-（4-methylbenzylamino）ethyl] ethane-1,2-diamine and its transitional metal complexesCl（M=CuⅡ,CoⅡ,NiⅡ） have been synthesized.Their composition and structures were characterized by elementary analysis,1HNMR,FTIR and molar conductance.The crystal structure of Ni-L was determined by the single crystal X-ray diffraction method.L is a tridentate ligand,which coordinates to Ni atom with 1∶ 1,and all of the complexes have the similar six-coordinated octahedral structures.In addition,the interaction of complexes with the calf thymus DNA was investigated by UV spectroscopy and fluorescence spectroscopy.The results suggested that the complexes may be combined to DNA by the electrostatic interaction mode.The combining constants（Cu-L,Ni-L,Co-L） are 2.99×104,9.78×103 and 3.66×103,respectively.

关 键 词：配合物 DNA 生物活性 相互作用 单晶结构 医药原料 

分 类 号：O621.2[理学—有机化学]