原因不明习惯性流产危险因素1：2病例对照研究  

A 1:2 Matched Case-Control Study on Risk Factors of Unexplained Recurrent Spontaneous Abortion

作　　者：王燕[1] 刘银梅[2] 戴以恒[1] 赵静[1] 袁伟[3] 沈月平[2] 

机构地区：[1]苏州大学医学部放射医学与公共卫生学院2007级放射医学,江苏215213 [2]苏州大学医学部放射医学与公共卫生学院流行病与卫生统计教研室 [3]上海市计划生育科学研究所国家人口计划生育委员会计划生育药具重点实验室

出　　处：《中国慢性病预防与控制》2011年第1期49-51,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家自然科学基金(3082176);苏州大学医学发展基金重点项目(EE126765);国家级大学生创新性试验计划项目(5731503110)

摘　　要：目的探讨原因不明习惯性流产的相关环境危险因素,为预防习惯性流产提供科学依据。方法采用流行病学1:2配比的病例-对照研究方法,对60例原因不明习惯性流产者和120例正常怀孕妇女相关流行病学资料进行了调查。应用SAS8.1软件对调查因素进行单因素及多因素条件Logistic回归分析。结果原因不明习惯性流产的主要危险因素是低学历(OR=10.82,95%CI:2.49～47.04)、生殖道感染(OR=3.53,95%CI:1.44～8.62)、丈夫饮酒(OR=4.75,95%CI:1.48～15.22)、现居地每日噪音暴露时间大于6h(OR=5.39,95%CI:1.03～28.22)、新家具有气味(OR=2.33,95%CI:1.07～5.06)。孕期被动吸烟、居地噪音暴露程度的增加可能与习惯性流产的发生有关联。结论低学历、生殖道感染、丈夫饮酒、现居地每日噪音暴露时间大于6h、新更换家具有气味是原因不明习惯性流产的危险因素,孕期被动吸烟可能与习惯性流产有关。Objective To investigate the environmental risk factors of unexplained recurrent spontaneous abortion. Methods A 1：2 matched case-control study was carried out in Suzhou including 60 cases and 120 controls. Data were analyzed with univariate and multivariate conditional Logistic regression using SAS 8.1. Results The analysis showed that main risk factors of unexplained recurrent spontaneous abortion were low level of education （OR =10.82, 95% CI：2.49-47.04）, infections of reproduotive tract （OR=3.53, 95%CI：1.44-8.62）, husband alcohol drinking （OR=4.75, 95%CI：1.48-15.22）, the noise exposure time more than 6 hours in current residing place （OR=5.39, 95%CI： 1.03-28.22）, new furniture odor （OR=2.33, 95%CI： 1.07-5.06）. Passive smoking during pregnancy, the levels of noise exposure increased in current residing may be environmental risk factors of recun＇ent spontaneous abortion. Conclusion The study showed that the risk factors of unexplained recurrent spontaneous abortion were including low level of education, infections of reproductive tract, husband alcohol drinking, the noise exposure in current residing, new furniture odor. Passive smoking during pregnancy, the levels of noise exposure increased in current residing may be related to recurrent spontaneous abortion.

关 键 词：流产 习惯性 病例对照研究 危险因素 

分 类 号：R181.3[医药卫生—流行病学]