尿道致病性大肠杆菌I型菌毛的研究进展  

Research Advances on Type 1 Pilus of Uropathogenic Escherichia coli

作　　者：杨东靖[1,2] 葛新[3] 李力[1,2] 

机构地区：[1]天津市疾病预防控制中心病原生物检测所,300011 [2]天津市预防医学研究所,300011 [3]武警医学院微生物教研室,天津300162

出　　处：《中国慢性病预防与控制》2011年第1期101-103,共3页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家自然科学基金资助项目(81000707)

摘　　要：泌尿道感染(Urinary tract infections,UTIs)是世界范围内严重的公共卫生问题。尿道致病性大肠杆菌(Uropathogenic Escherichia coli,UPEC)是引发UTIs的首要致病菌。I型菌毛是UPEC重要的毒力因子,在UPEC中分布广泛,介导其在泌尿道的粘附、侵入和定植。该文对UPECⅠ型菌毛的结构、装配和毒力机制进行综述。Urinary tract infections are serious public health problem worldwide. Strains of uropathogenic Escherichia coli （UPEC）are the primary cause of urinary tract infections. Type 1 pilus of UPEC is a very important virulence factor,widely distributed in UPEC,and mediates its adhesion, invasion and colonization in the urinary tract. The structure, assembly and virulence mechanism of type 1 pilus were reviewed in this paper.

关 键 词：泌尿道感染 尿道致病性大肠杆菌 I型菌毛 

分 类 号：R378.2[医药卫生—病原生物学]