D-二聚体、纤维蛋白原与冠状动脉病变程度及左心功能的关系  

Relationship between D-dimer,fibrinogen and coronary artery disease and left ventricular function

作　　者：董琦[1] 牛凡[1] 杨涓[1] 

机构地区：[1]山西医科大学心内科,太原030001

出　　处：《中国医疗前沿》2011年第2期3-4,共2页China Healthcare Innovation

摘　　要：目的探讨D-二聚体(DD)、纤维蛋白原(Fbg)与冠状动脉病变程度及左心功能的关系。方法选取92例冠心病CH患者,其中稳定型心绞痛患者28例,不稳定心绞痛(UA)患者34例,急性心肌梗死(AMI)30例,并设30例正常对照组。分别测以上各组DD及Fbg含量,并根据冠脉造影结果将冠心病组分为单支病变组36例、两支病变组29例、三支病变组27例,根据血分数(LVEF)分为左心功能正常和左心功能不全组,分别进行DD及Fbg的比较。结果 AMI、UA组DD、Fbg含量明显高对照组(P<0.01);AMI组DD明显高于UA组(P<0.05);AMI组和UA组的FG比较差异无显著性(P>0.05)。冠脉两、三支变组FG和DD含量高于对照组和一支病变组,差异显著(P<0.01),三支病变组高于两支病变组(P<0.05),对照组和一支病组差异无显著性(P>0.05)。左心功能不全组Fbg浓度高于左心功能正常组,但左心功能不全组DD浓度与左心功能正常组显著差别。结论血浆纤维蛋白原和D-二聚体的升高是冠心病事件的表现和依据,并可能与冠脉病变的严重程度相关。Objective The purpose of D-dimer（DD）,fibrinogen（Fbg） and coronary artery and left heart function.Methods 92 cases of CHD patients,28 patients with stable angina,unstable angina（UA） patients,34 patients with acute myocardial infarction（AMI） 30 patients and 30 normal controls established.DD and Fbg levels in each group were measured above,and coronary heart disease based on results of coronary angiography group was divided into single-vessel disease in 36 patients,29 patients with two lesions,three lesions in 27 cases,according to ejection fraction（LVEF） divided into normal left ventricular function and left ventricular dysfunction group,respectively,for DD and Fbg comparison.Results In AMI,UA group DD,Fbg were significantly higher（P0.01）;AMI group was significantly higher than that of UA DD group（P0.05）;AMI group and the UA group,FG was no significant difference between（P0.05）.Coronary two,three lesion groups FG and DD level was higher and a disease group,the difference was significant（P0.01）,three lesions were higher than two lesions（P0.05）,a disease control group and no significant difference between groups（P0.05）,left ventricular dysfunction group Fbg concentrations higher than normal left ventricular function,left ventricular dysfunction group but DD concentration and normal left ventricular function was not significantly difference.Conclusion The plasma fibrinogen and elevated D-dimer and coronary heart disease based on the performance of the event,and may be related to the severity of coronary artery disease.

关 键 词：D-二聚体 纤维蛋白原 冠心病 左心功能 

分 类 号：R541.4[医药卫生—心血管疾病]