离子电渗给药技术的研究进展  

Progress in research of iontophoretic delivery systems

作　　者：李丁[1] 程志红[1] 吴闻哲[1] 

机构地区：[1]药物制剂国家工程研究中心,上海201203

出　　处：《中国新药杂志》2011年第5期411-416,共6页Chinese Journal of New Drugs

基　　金：重大新药创制科技重大专项(2009ZX09310-003)

摘　　要：离子电渗技术作为一种非侵袭性给药方法已经研究了很多年,其作用机制已经广为人们所熟知并以此推动离子电渗给药系统的发展。该技术利用微量电流帮助解离、极性和中性药物分子透过机体屏障。它能够根据患者的自身情况调整治疗方案,这可以减少治疗时蛋白类药物的个体差异,影响药物代谢,进而提高治疗效果。本文综述了近年来离子电渗给药技术的研究进展、影响因素、新的给药途径以及与其他促渗技术的联合应用。Iontophoresis as a non-invasive technique has been investigated for many years.Significant achievements have been made in the understanding of mechanisms underlying iontophoresis,which have contributed to the rational development of iontophoretic delivery systems.The application of a small electric current has enhanced the transport of charged,polar,and neutral compounds across the body.The principal distinguishing feature is the control afforded by iontophoresis and the ability to individualize therapies.This may become significant impact on interindividual variations in protein expression,and may be beneficial to drug metabolism and improvement of drug efficacy.This review focused on the progress in research of iontophoretic delivery systems,factors influencing iontophoretic process,new administration routes and conjunction with other enhancing technologies.

关 键 词：离子电渗 促渗技术 透皮吸收 黏膜 

分 类 号：R944.9[医药卫生—药剂学]