邻苯二甲酸二酯与特发性弱精子症的关系  

Study of di - 2 - ethylhexyl phthalate and idiopathic asthenospermia

作　　者：杨波[1] 高佃军[1] 吴瞳[1] 王凯[1] 

机构地区：[1]潍坊医学院,山东261053

出　　处：《国际泌尿系统杂志》2011年第2期156-158,共3页International Journal of Urology and Nephrology

摘　　要：目的检测人精浆中邻苯二甲酸二酯（DEHP）的浓度来评价DEHP对特发性弱精子患者精液质量的影响。方法选择特发性弱精子患者50例，非特发性弱精子患者50例，精液正常者50例，分别用非特发性弱精子患者组及精液正常者组作为对照组。运用反相液相高效色谱法测定血浆及精浆中DEHP浓度。并运用SPSS分析软件测定结果进行了分析。结果特发性弱精子患者组中DEHP均可检出，含量范围在精液中为ND0．10～1．5mg／L；非特发性弱精子患者组及精液正常组DEHP分别检出15例及13例，精液中为ND0—0．96mg／L和ND0～0．95mg／L；特发性弱精子组与非特发性弱精子组和正常组精浆中DEHP的浓度有差异（P〈0．05），非特发性弱精子症患者组与正常组精浆中DEHP浓度无差异（P〉0．05），精浆中DEHP浓度与精子活力负相关（P〈0．05）。结论精浆中DEHP可以影响精子质量。Objectives To detect the level of di - 2 - ethylhexyl phthalate（DEHP） in serum and semen to evaluate effect of DEHP to idiopathic asthenaspermia. Methods 150 people were assigned into idiopathic asthenaspermia group （ n = 50 ） , no idiopathic asthenaspermia group （ n = 50 ） and nomal group （ n = 50 ）. The concentrations of DEHP in the human biological samples were measured by using reversed - phase HPLC. Results The DEHP were detected in most of the idiopathic asthenaspermia group 0.10 - 1. 5 mg / L in semen specimens, 15 of no idiopathic asthenaspermia group 0 -0.96 mg/L in semen specimens, 13 of nomal group 0 -0.95mg/L in semen specimens. There was difference between semen concentrations of DEHP and sperm molity（ p 〈 0.05 ）. Conclusions These results suggest that DEHP affect semen quanlity,specialy DEHP in semen specimens.

关 键 词：少精液症 

分 类 号：R698.2[医药卫生—泌尿科学]