老慢气患者下呼吸道微生态学的研究  

STUDIES ON MICROECOLOGY IN LOWER RESPIRATORY TRACT OF PATIENTS WITH SENILE AND CHRONIC BRONCHITIS

作　　者：肖纯凌[1] 李舒音[1] 韩秀珍[2] 蒋义玲 金瑶丽[3] 刘重光[3] 

机构地区：[1]沈阳医学院微生物教研室 [2]沈阳第四人民医院检验科 [3]沈阳医学院附属第二人民医院呼吸内科

出　　处：《中国微生态学杂志》1999年第4期220-221,224,共3页Chinese Journal of Microecology

基　　金：辽宁省科委资助

摘　　要：为深入探讨老慢气的发病机理，运用微生态学原理对３２例老慢气患者下呼吸道以纤难支气管镜和环甲膜穿刺的方法采取气管分泌物标本，以进一步探讨老慢气患者与菌群失调的关系。结果表明，老慢气患者下呼吸道需氧菌主要为肺炎链球菌、奈瑟菌、甲型链球菌。肺炎链球菌和奈瑟菌的检出率分别为５０％和４３７５％。厌氧菌主要为消化链球菌、韦荣菌、优杆菌、丙酸杆菌。消化链球菌检出率为８７５％，韦荣球菌为３４３８％。药敏实验表明，肺炎链球菌中有９３７５％对氨苄青霉素敏感，８１２５％对先锋霉素５敏感。甲型链球菌有８７５％对青霉素和氨苄青霉素敏感，６２５％对菌必治和复达欣敏感提示在使用抗生素前必须做药敏试验，注重菌群平衡。研究进一步表明了下呼吸道和肺部感染由患者异常定植的菌群引起。Senile and chronic bronchitis,incidence of which is up to 15%,is a common frequently-occurring disease in the world.To elaborate occurrence mechanism of senile and chronic bronchitis and imbalance relationship between its patients and their bacterium group,the trachea secretion in lower respiratory tract of the 32 patients was collected with the methods of fibrous bronchus mirror and puncture of cricothyroid membrane.The results showed that the aerophil bacteria mainly were S.pneumoniae,Neisseria,a-hemolytic Streptococcus.The determination rateof S.pneumoniae was 50%,Neisseria 43.75%.The aerophobic bacteria mainly were Peptostreptococcus,Veillonella,Eubacterium,Propionibacterium.The determination rate of Peptostreptococcus was 87.5%,Veillonella 34.38%.The test of drug susceptibility indicated that 93.75% of S.pneumoniae was sensitive to amino-benzyl penicillin,81.25% to cephalosposin-5,and that 87.55 of a-hemolytic streptococcus was sensitive to penicillin and amino-benzyl penicillin,62.5% to cefatrizine and fortum.It indicated that the test of drug susceptibility and notice the balance among bacteria group to the patients must be done before using antibiotic.The results also showed that the infection of the lower respiratory tract and the lung were caused from abnormal placed of the bacteria group.

关 键 词：呼吸道 微生态学 菌群平衡 药敏试验 支气管炎 

分 类 号：R562.210.2[医药卫生—呼吸系统]