刺激大鼠离断背根外周端对相邻背根电活动的影响  

EFFECT OF STIMULATING THE PERIPHERAL ENDINGS OF TRANSECTED DORSAL ROOT ON DISCHARGES OF NEIGHBOURING DORSAL ROOT IN RATS

作　　者：张勇[1] 邓云平[1] 关新民[1] 

机构地区：[1]同济医科大学神经生物学教研室,武汉430030

出　　处：《生理学报》1999年第4期371-376,共6页Acta Physiologica Sinica

基　　金：国家攀登计划经络研究资助项目

摘　　要：在切断大鼠左侧Ｌ２ 、Ｌ３ 背根后， 观察电刺激（ 刺激参数为０－８ ～１－２ ｍＡ，１００ Ｈｚ，０－５ｍｓ，总时程２ ｓ）Ｌ２ 背根外周端对Ｌ３ 背根放电活动的影响。结果表明： 连续多次刺激Ｌ２ 背根可使Ｌ３ 背根平均放电频率（ＭＤＦ） 逐步增加， 增加量与刺激次数呈明显直线正相关。各次刺激后的时程分析表明， 这种增频作用具有明显的累积效应和后效应， 并与刺激前Ｌ３ 背根的活动状态密切相关， 刺激前放电活动较强者其增频作用更明显。结果提示，The dorsal roots(DR)of L2～L3 segments on the left side in anesthetized rats ( n =28) were exposed and transected. After stimulating the peripheral endings of L2 DR with a train of square waves (0 8～1 2 mA, 100 Hz, 0 5 ms) for 2 s, the discharges at the distal end of transected L3 DR were recorded for 120 s. We found that the mean discharge frequency (MDF) of L3 DR was gradually increased with L2 DR stimulation. Time course analysis showed that the increase in MDF was linearly correlative to the number of stimuli, as well as to the levels of spontaneous discharge of L3 DR. The above results suggest that the transegmental information transmission between peripheral endings of primary sensory neurons may occur through a chemical non synaptic way.

关 键 词：背根 感觉神经末梢 信息传递 电生理 

分 类 号：Q424[生物学—神经生物学] Q429[生物学—生理学]