鲫鱼视网膜亮度型水平细胞上不同视锥信号的相互作用: 实验及模型(英文)  

INTERACTION OF CONE SIGNALS ON L TYPE HORIZONTAL CELL IN CARP RETINA: EXPERIMENTS AND MODELING 

作　　者：梁培基[1] 

机构地区：[1]中国科学院上海生理研究所神经生物学开放实验室,上海200031

出　　处：《生理学报》1999年第4期377-385,共9页Acta Physiologica Sinica

基　　金：中国科学院留学经费择优支持;中国科学院生物科学与技术研究特别支持费;国家自然科学基金

摘　　要：本文应用胞内记录和动态模型分析方法， 研究了离体鲫鱼视网膜视锥驱动的亮度型水平细胞（ＬＨＣ） 上不同视锥信号的相互作用。实验表明， 绿背景光的作用可以提高ＬＨＣ的红光反应， 这种增强作用与绿敏视锥的活动程度密切相关。模型分析表明， 绿背景光的作用使谷氨酸介导的前馈性通路和ＧＡＢＡ 介导的反馈性通路活动同时得以增强。水平细胞对光反应的增强效应不能为外源性ＧＡＢＡ所消除， 而其程度为前馈性通路和反馈性通路活动增加的相对程度所决定。Intracellular recordings were made from the luminosity type cone driven horizontal cells (LHCs) in the isolated carp retina and model analysis was performed to investigate possible mechanisms underlying the interaction of different cone signals converging onto these cells. It was observed that a green background light enhanced the LHC′s red response, and such enhancement was closely related to the activation of green cones. Model analysis showed that the activity of both glutamate and GABA related pathways were potentiated during green background illumination. GABA application did not abolish the response enhancement. It is speculated that the extent of the LHC′s response enhancement may be determined by the balance of the increased activity between the feedforward and feedback pathways.

关 键 词：鲫鱼 视网膜 水平细胞 相互作用 模型 

分 类 号：Q436[生物学—生理学]