腹腔镜CO_2气腹对早期妊娠组织中VEGF及TNF-α的影响  

Effect of Carbon Dioxide Pneumoperitoneum on VEGF and TNF-α in Early Pregnant Tissue

作　　者：陈颖[1] 何鞠颖 林文毅[1] 罗剑儒 杨延林[2] 

机构地区：[1]四川省成都市妇幼保健院,四川成都610041 [2]四川大学华西第二医院,四川成都610041

出　　处：《实用妇产科杂志》2011年第2期149-151,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨CO2气腹对早期妊娠组织中血管内皮生长因子(VEGF)及肿瘤坏死因子-α(TNF-α)的影响。方法:分为研究组和对照组(每组10例)两组,研究组:选择早期妊娠合并子宫附件良性包块,且没有继续妊娠要求的患者,在腹腔镜下行子宫附件良性包块剥除术后行人工流产术。对照组:选择早期正常妊娠,要求终止妊娠的患者。两组人工流产术后取胚胎组织进行免疫组化,比较胚胎组织中VEGF及TNF-α表达情况。结果:研究组中胚胎组织中的VEGF和TNF-α的表达均较对照组明显增加(P<0.05)。结论:CO2气腹对早期妊娠组织有影响,腹腔镜在合并早期妊娠的患者中的应用需谨慎。Objective：To investigate the effect of carbon dioxide pneumoperitoneum on vascular endothelial growth factor （VEGF） and tumor necrosis factor （TNF）α in early pregnant tissue. Methods：10 patients were in experimental group and 10 in control group. Early pregnant patients with uterine or adnexal benign mass and no subsequent desiring pregnancy were selected as experimental group. In this group induced abortion was done after laparoscopic operation. Early pregnant patients with induced abortion were selected as control group. Immunohistochemical assay was performed in embryonic tissue after induced abortion in two groups for comparison the expression of VEGF and TNF-α in embryonic tissue. Results：The expression of VEGF and TNF-α in embryonic tissue in experimental group was significantly higher than that in control group（P〈0.05）. Conclusions：Because carbon dioxide pneumoperitoneum can affect early pregnancy,laparoscope should be carefully used in early pregnant patient.

关 键 词：CO2气腹 早期妊娠 血管内皮生长因子 肿瘤坏死因子-Α 

分 类 号：R714[医药卫生—妇产科学]