外源性肺表面活性物质治疗新生儿呼吸窘迫综合征30例临床分析  

Clinical analysis of 30 examples about external surfactant on neonatal respiratory distress syndrome

作　　者：郭本标[1,2] 张俊 王慧琴 汪家安[1,2] 尹晓光[1,2] 

机构地区：[1]合肥市妇幼保健院新生儿科,230061 [2]安徽医科大学妇幼保健临床学院

出　　处：《安徽医学》2011年第2期190-191,共2页Anhui Medical Journal

摘　　要：目的观察肺表面活性物质固尔苏治疗新生儿呼吸窘迫综合征的效果。方法 30例患儿应用固尔苏,随即予以鼻塞式CPAP治疗,观察治疗后临床反应、血气分析的变化及疗效。结果应用固尔苏后患儿呼吸困难、呻吟、三凹征、发绀症状减轻或消失,患儿用药后30 min均下调CPAP参数;患儿用药前后PaO2、PaCO2、pH的比较差异有统计学意义(P<0.001);其中25例患儿痊愈出院,5例患儿好转出院。结论肺表面活性物质固尔苏治疗新生儿呼吸窘迫综合征的疗效较好。Objective To observe the effects of surfactant on neonatal respiratory distress syndrome.Methods 30 NRDS undergone the treatment with pulmonary surfactant and then with the CPAP of stuffynose type were observed for clinical response,the changes of blood gas idex and therapeutic effects.Results After the administration of pulmonary surfactant,the symptoms as dyspnea,retarded expiration,three depressions sign and cynanosis were lessened and disappeared.The parametersn of the CPAP was slowed down at 30 minutes after treament with pulmonary surfactant.The difference was significant when PaO2,PaCO2,pH were compared with pre-medication（P0.001）.Conclusion The pulmonary surfactant can effectively impove the lung function and clinical sympton of the neonatal respiratory distress syndrome.

关 键 词：肺表面活性物质 呼吸窘迫综合征 新生儿 

分 类 号：R722.1[医药卫生—儿科]