盐酸可乐定治疗重症手足口病的探讨  

Clinical observation of clonidine hydrochloride in the treatment of severe hand-foot-mouth disease

作　　者：髙有方 吕勇[2] 王兴民[1] 白连伟[1] 张雪雷[1] 李志刚[1] 

机构地区：[1]毫州市人民医院感染科,236800 [2]安徽省立医院儿科

出　　处：《安徽医学》2011年第2期192-194,共3页Anhui Medical Journal

摘　　要：目的观察盐酸可乐定干预治疗重症手足口病(HFMD)的临床疗效。方法采取随机、对照的研究方法,将57例重症HFMD患儿随机分为对照组、可乐定治疗组。比较两组患儿在ICU机械通气率、肺水肿/出血发生率、平均ICU入住时间等。结果治疗组与对照组患儿在机械通气率、肺水肿/出血发生率、平均入住ICU时间分别为20.00%、13.33%、(4.13±2.13)d、和44.44%、37.03%、(5.9±2.3)d,两组相比,差异均有统计学意义(P值均<0.05)。结论盐酸可乐定干预治疗重症HFMD,可降低肺水肿/出血发生,减少机械通气,缩短ICU入住时间。Objective To observe the efficacy of clonidine hydrochloride in the treatment of severe hand,foot and mouth disease（HFMD）.Methods This prospective one-center observational study was carried out in a Infectious Diseases Intensive Care Unit（ICU） from March to August in 2010.57 cases of severe HFMD were randomly divided into two groups： control group and clonidine treatment group.The incidence of pulmonary edema/hemorrhage,mechanical ventilation,and the duration of ICU stay were compared between the two groups.Results The duration of ICU stay,the incidence of pulmonary edema or pulmonary hemorrhage and the rate of mechanical ventilation were（4.13±2.13）days,13.33%,20.00% respectively in the treatment group,and 5.9±2.3 days,37.03%,44.44% respectively in the control group（P0.05）.Conclusion Clonidine hydrochloride treatment of severe HFMD can improve clinical symptoms,reduce the rate of pulmonary edema/ hemorrhage and mechanical ventilation,shorten the duration of ICU stay.

关 键 词：手足口病 重症 可乐定 治疗 

分 类 号：R725.1[医药卫生—儿科]