慢性肾脏病对高龄患者血栓弹力图检测的影响  

Application of thrombelastography on coagulative function detection in elderly patients with chronic kidney disease

作　　者：敖强国[1] 邹慧[1] 马强[1] 李健[1] 王晓华[1] 程庆砾[1] 

机构地区：[1]解放军总医院南楼临床部肾内科,北京100853

出　　处：《中华保健医学杂志》2011年第1期15-18,共4页Chinese Journal of Health Care and Medicine

摘　　要：目的利用改良的血栓弹力图技术研究高龄慢性肾脏病(CKD)患者凝血功能变化。方法选取我院南楼临床部住院的高龄非透析CKD患者32例为CKD组,选取同期住院的高龄非CKD患者38例为对照组。对比分析两组患者血栓弹力图及常规凝血指标变化。结果与对照组比较,CKD组患者Kthrombin显著减少(1.38±0.29vs1.94±0.50min),MAthrombin、综合凝血指数、AngleFibrin、MAFibrin和血浆纤维蛋白原显著增加(64.40±4.46vs58.53±4.15mm)、(7.47±0.81vs6.68±0.84)、(62.95±6.29vs54.60±8.00deg)、(20.57±10.89vs11.15±4.50mm)、(3.87±0.99vs3.24±0.68g/L),差异均有统计学意义(P<0.01)。结论高龄CKD患者存在高凝状态,CKD是综合凝血指数升高的独立危险因素。Objective To investigate the changes of coagulative function in elderly patients with chronic kidney disease（CKD）by using thrombelastography（TEG）.Methods Thirty-two non-dialysis CKD elderly patients（mean age 84.61 years）and 38 patients without CKD（mean age 85.03 years）designed as CKD group and control group.Comparative analysis on the thrombelastogram and conventional blood coagulative parameters were used in the two groups.Results Compared with the control group,Kthrombin of CKD group was significantly decreased（P0.01）,while MAthrombin,AngleFibrin,MAFibrin and the level of serum fibrinogen were significantly increased（P0.01）.Conclusions The elderly patients with CKD were in hypercoagulable state,CKD was independent risk factor of clot index（CI）.

关 键 词：慢性肾脏病 凝血 血栓弹力图 

分 类 号：R692[医药卫生—泌尿科学]