2008～2009年铜绿假单胞菌的分离率及耐药情况分析  

Isolation of Pseudomonas aeruginosa and drug resistance during year 2008～2009

作　　者：夏静鸿[1] 林玮[1] 李夏明[1] 李京明[1] 刘双[1] 

机构地区：[1]首都医科大学附属北京安贞医院感染科,北京100029

出　　处：《临床肺科杂志》2011年第4期493-496,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的分析引起医院感染的铜绿假单胞菌（PAE）的分离率及耐药情况,为配合临床更好的诊治提供依据。方法回顾性分析2008~2009年我院共215株PAE的分离率及耐药情况,采用SPSS13.0统计软件进行统计学分析。结果 PAE占总G-菌株的13.05%,位居院内临床分离G-杆菌的第二位;主要分布于ICU和呼吸内科,送检标本以痰液为主。对抗菌药物的敏感率：阿米卡星〉妥布霉素〉哌拉西林/他唑巴坦〉亚胺培南〉环丙沙星〉庆大霉素〉左氧氟沙星〉头孢他啶〉50%。IRPA组中有72.22%发生于ICU内;且对多种抗菌药物的敏感率低于ISPA组。ICU组较非ICU组相比,其PAE对亚胺培南、头孢他啶等敏感率明显降低。结论 PAE是引起医院内感染的常见致病菌,ICU及呼吸内科常见,痰液中分离率最高。我院PAE对阿米卡星的敏感率最高。IRPA多见于ICU,且对多种抗菌药物的敏感率下降。ICU内易出现耐药菌株,应严格监控。Objective Analysing the separation rate and resistance changes between 2008 to 2009 of Pseudomonas aeruginosa（PAE） which is the main pathogen causing hospital-acquired infections for better clinical diagnosis and treatment.MethodsThe date of 215 PAE separations bwteen 2008 to 2009 in my hospital were analysed with the SPSS13.0 statistics software.ResultsPAE consisted 13.05% of.the total G-strain and ranks the second in G-bacteria of nosocomial clinical isolates.PAE mainly distributed in the ICU and the department of respiratory medicine Antibiotic sensitivity rates： amikacinTobramycin piperacillin/tazobactamimipenemciprofloxacingentamicinlevofloxacinceftazidime50%.IRPA group occurred in 72.22% in ICU;and sensitive to many antimicrobial drugs was lower than ISPA group.ICU group than in non-ICU group compared to the PAE of imipenem,ceftazidime and other sensitive rate was significantly lower.ConclusionsPAE is a common pathogenic bacteria which causes infection in hospital especially in ICU and the department of respiratory medicine.PAE was sensitive to amikacin.IRPA was not sensitive to many antibiotics.

关 键 词：铜绿假单胞菌 分离率 耐药情况 

分 类 号：R446.5[医药卫生—诊断学]