经颅磁刺激对脑损伤儿童脑氧合和组织灌注影响的初步研究  

Primary Research of the Influence of Transcranial Magnetic Stimulation on Brain Oxygenation and Tissue Perfusion in Children with Brain Injury

作　　者：蒋滔滔[1] 洪琦[1] 卓秀慧[1] 高延[1] 罗小杏[1] 

机构地区：[1]深圳市宝安区妇幼保健院,广东深圳518133

出　　处：《医学临床研究》2011年第2期252-253,256,共3页Journal of Clinical Research

基　　金：2007年深圳市科技局立项课题（项目编号200703016）

摘　　要：[目的]探讨经颅磁刺激对脑损伤儿童脑氧含量和脑组织灌注以及神经心理发育的影响.[方法]用近红外光谱技术检测每组脑损伤儿童脑组织经颅磁刺激治疗前和治疗2个月后还原血红蛋白浓度（CHb）和氧合血红蛋白浓度CHbO2的变化值及反应脑氧合的氧饱和度（rSO2）绝对值,进一步得到反应脑灌注的CHbD=CHbO2-CHb 应用婴幼儿智能测查量表测查每组儿童治疗前后神经心理发育 用成组t检验比较各组的变化.[结果]经颅磁刺激2个月后,对照组脑氧含量和脑组织灌注显著增加,神经心理测查（CDCC）显著提高（P〈0.05）.[结论]经颅磁刺激能显著提高脑损伤儿童的脑氧合和组织灌注,促进大脑发育.[Objective] To explore the effect of transcranial magnetic stimulation on brain oxygenation, tissue perfusion and neuropsychological development in brain injury children. [Methods] The children with brain injury received transcranial magnetic stimulation therapy. Before treatment and after treatment for 2 months, near-infrared spectroscopy was used to detect the changes of reduction hemoglobin CHb and oxygenation hemoglobin CHbO2, and the absolute value of O2 saturation rSO2. The brain perfusion CHbD（CHbO2- CHb） was further obtained. The scale of infant intelligent development was used to assess neuropsychological development in children before and after treatment. The changes in each group were compared by group t-test. [Results] After treatment for 2 months, the oxygen content and brain tissue perfusion increased significantly, and the neuropsychological measurement （CDCC） was improved obviously（ P〈0.05）. [Conclusion] Tran- scranial magnetic stimulation can significantly increase brain oxygenation and tissue perfusion, and promote the development of brain.

关 键 词：脑损伤 电磁场 氧 

分 类 号：R651.15[医药卫生—外科学]