不同时间补救ICSI结局的比较分析  

Comparison and analysis on outcomes of rescue ICSI at different times

作　　者：王美仙[1] 邵小光[1] 张振强[1] 裘娟[1] 

机构地区：[1]辽宁省大连市妇产医院生殖中心,116021

出　　处：《中国妇幼保健》2011年第7期1047-1049,共3页Maternal and Child Health Care of China

摘　　要：目的:比较分析常规体外受精(IVF)后6 h和20 h补救卵细胞浆内单精子显微注射(ICSI)应对受精障碍的优劣。方法:489周期IVF后6 h推测是否受精(6 h组),620周期IVF后20 h确认是否受精(20 h组),比较两组中受精率为0～30%和0的实验室指标。结果:IVF受精率0～30%的周期中,6 h组2PN受精率、胚胎数、冷冻胚胎数和可移植的胚胎数显著高于20 h组,妊娠率和种植率高于20 h组,但无统计学意义。IVF受精率为0的周期中,6 h组补救ICSI后获得的2PN受精率、优质胚胎数、≥5细胞胚胎数、冷冻胚胎数及妊娠率显著高于20 h组,差别有统计学意义。结论:IVF后6 h补救ICSI的结局优于20 h补救ICSI者。Objective：To compare and analyze the advantages and disadvantages of rescue intracytoplasmic sperm injection（ICSI） at 6 hours and 20 hours after IVF to cope with fertilization failure. Methods：489 cycles were presumed fertilization or not at 6 hours after IVF（6-hour group）,620 cycles were presumed fertilization or not at 20 hours after IVF（20-hour group）,the laboratory indexes in the two groups were compared when the fertilization rates were 0~30% and 0,respectively. Results：When the fertilization rate was 0~30%,the 2PN fertilization rate,the number of embryos,the number of frozen embryos and the number of transplanted embryos in 6-hour group were significantly higher than those in 20-hour group;the pregnancy rate and implantation rate in 6-hour group were higher than those in 20-hour group,but there was no significant difference;when the fertilization rate was 0,the 2PN fertilization rate,the number of good quality embryos,the number of ≥5 cells embryos,the number of frozen embryos and pregnancy rate in 6-hour group were significantly higher than those in 20-hour group. Conclusion：The outcomes of rescue ICSI at 6 hours after IVF are superior to those at 20 hours after IVF.

关 键 词：受精障碍 IVF 补救ICSI 

分 类 号：R321.2[医药卫生—人体解剖和组织胚胎学]