染料木素的神经保护作用及其机制的研究进展  

Research progress on neuroprotective effect and its mechanisms of genistein

作　　者：罗思婧[1] 黄庆 任冬冬[1] 廖维良[1] 杨红[1] 

机构地区：[1]广东药学院基础学院,广东广州510006 [2]广州市拜澳生物科技有限公司,广东广州510630

出　　处：《广东药学院学报》2011年第1期94-98,共5页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省社会发展计划工业攻关项目(2005B10401005);广东省科技计划农业攻关项目(2010B020312016)

摘　　要：染料木素广泛存在于豆科植物中,其作为植物雌激素应用于制药、营养保健品等领域。研究表明,染料木素可以通过抗氧化、抗Aβ毒性、调节神经营养因子的表达、调节细胞内Ca2+浓度、减轻谷氨酸的神经毒性、抑制神经细胞的凋亡、调节信号转导通路以及增加海马神经肽Y的表达等作用机制,从而发挥神经保护作用。本文综述染料木素的神经保护作用及其机制的研究进展。Genistein widely exists in legumes, and as a phytoestrogen, is applied in pharmaceutical industry, nutritional products and so on. It is proved that genistein has neuroprotective effects through the mechanisms of anti-oxidation, resisting A beta（Aβ） toxicity, adjusting neurotrophic factor expression, regulating intracellular Ca2＋ concentration, reducing the neuro-toxicity of glutamine, inhibiting the nerve cell apoptosis, regulating signal transduction pathway and increasing the hippocampus neuropeptide Y expression, etc. Based on domestic and overseas scholars＇ researches in recent years on the treatment of Alzheimer＇s disease （AD） with genistein, developments of the neuroprotective effects of genistein are reviewed.

关 键 词：染料木素 神经保护 阿尔茨海默病 

分 类 号：R285.5[医药卫生—中药学]