壳聚糖在口服结肠定位给药系统中的应用  

The application of chitosan in the oral colon-specific drug delivery system

作　　者：卢晓慧[1] 周毅生[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《广东药学院学报》2011年第1期99-103,共5页Academic Journal of Guangdong College of Pharmacy

摘　　要：壳聚糖是甲壳素脱乙酰化的产物,具有来源广泛、低毒、生物相容性好以及能够被生物降解等特性,是多种口服给药系统的良好载体,尤其在结肠定位系统中应用广泛。本文对壳聚糖理化性质、结构以及其在口服结肠定位给药系统中的应用作一综述。Chitosan is the outcome of chitin＇s deacetylation,which has a wide range of sources. Chitosan is a good carrier for many oral drug delivery systems, especially the oral colon-specific drug delivery system, for its low toxicity, good biocompatibility and biodegradability. The physiochemical property, structure and application in oral colon specific drug delivery system of chitosan are reviewed.

关 键 词：壳聚糖 结肠定位 给药系统 理化性质 

分 类 号：TQ460.4[化学工程—制药化工] R944.9[医药卫生—药剂学]