缺血/再灌注肺损伤机制的研究进展  

The Research of Lung Injury Induced by Ischemia/Reperfusion

作　　者：曲文超[1] 林春榕[2] 吴学东[1] 

机构地区：[1]大理学院附属医院小儿外科,云南大理671000 [2]大理学院临床医学研究中心,云南大理671000

出　　处：《医学综述》2011年第4期487-489,共3页Medical Recapitulate

基　　金：云南省自然科学基金(2009ZC121M)

摘　　要：缺血/再灌注(I/R)肺损伤可见于肺组织本身和肺外组织器官I/R导致肺损伤,是指缺血所致肺损伤在血流恢复后,肺损伤不但没有减轻反而加重的现象。肺组织对I/R注非常敏感,缺血及缺血后的血液再灌注不但能造成肺组织代谢紊乱和功能障碍,还可以对其结构造成破坏,而且由I/R注引起肺组织的损伤往往出现的较早。I/R肺损伤的病理、生理机制尚不清楚,近年来I/R肺损伤越来越来受到重视,其发生、发展机制的研究也成为外科领域的热点课题之一。Ischemia reperfusion（I/R）lung injury can be found in the lung of the Renter organization itself and other organizations I/R.I/R lung injury means there＇s a shortage of the lungs damage occurred in the bloodstream recovering lung damage did not reduce instead of phenomenon.lung is very sensitive in I/R,I/R after ischemia are not only can cause lung organization and function obstacle metabolic disturbances may also cause damage to its structure.And lung injury caused by I/R is usually early.Pathological physiological mechanism is unclear.In recent years,the I/R lung injury is to be heard,it happened to the development of the mechanism of the study also become hot topics of the surgical field.

关 键 词：缺血/再灌注 肺损伤 氧自由基 多形核中性粒细胞 

分 类 号：R655.3[医药卫生—外科学]