口服福氏2a和宋内氏痢疾双价活疫苗FS的双盲对照现场观察  

Double-blind Field Trial of Oral Live F2a-Sonne(FS) Dysentery Vaccine

作　　者：涂光理[1] 崔长法[1] 王建阳[1] 傅炳南[1] 张文平 张怀谨 刘明欣 何国占 杜琳[3] 靳志刚[3] 李生迪[3] 宋树珍[3] 王秉瑞[3] 

机构地区：[1]河南省卫生防疫站,郑州450000 [2]河南省长葛市卫生防疫站,长葛451000 [3]卫生部兰州生物制品研究所,兰州730046

出　　处：《中国生物制品学杂志》1999年第3期178-180,共3页Chinese Journal of Biologicals

摘　　要：将 2 6 2 30人随机分为 3组 ,分别服用高剂量、低剂量口服痢疾活疫苗FS和安慰剂 ,观察安全性和保护效果 ,由结果可以看出 ,FS菌苗安全可靠。在半年的观察期内 ,能产生 6 2 76 %的对FS型保护 ,其中对福氏 2a保护率 6 1 0 7% ,宋内氏保护率 72 48% ,对菌痢的总保护率达 5 2 0 2 % ,高。In order to observe the safety and protective effect of oral live F 2a Sonne(FS) dysentery vaccine, 26230 subjects were randomly divided into 3 groups. The 2 trial groups received high and low doses of the vaccine respectively, and the control group received placebo. The result showed that the FS vaccine was safe and reliable. During the following 6 months after immunization, the protective rates of the FS vaccine against F 2a , Sonne and F 2a +Sonne dysentery were 61.07%, 72.48% and 62.76% respectively, and that against all kinds of bacillary dysentery was 52.02%. However, no significant difference was observed between the protective rates of high and low dose groups.

关 键 词：细菌性痢疾 活疫苗 安全性 保护 

分 类 号：R516.401[医药卫生—内科学]