星形胶质细胞引起神经元超激发的作用机制分析  

An Analysis on The Mechanism of Astrocytes Cause Neuronal Hyper-Excitability

作　　者：刘建[1] 杨利建[1] 刘望恒[1] 贾亚[1] 

机构地区：[1]华中师范大学物理科学与技术学院生物物理研究所,武汉430079

出　　处：《生物物理学报》2011年第1期57-65,共9页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(10875049);教育部科学技术研究重点项目(108096)~~

摘　　要：实验发现,星形胶质细胞表面膜上有多种神经递质受体,能积极参与脑内的信号传导,并与多种神经性疾病相关。在锥体神经元和星形胶质细胞的耦合网络中,星形胶质细胞能接受外部刺激。本文研究了在神经元和胶质细胞耦合系统中,将谷氨酸刺激加载在星形胶质细胞上的情况,发现神经元出现超激发现象,而神经元超激发是癫痫疾病的一个重要特征之一;并分析了耦合强度对该系统的影响,发现耦合强度是引起神经元超激发的关键因素。这些结果对人们认识癫痫发生的生理机制具有一定的启发作用。It is found in experiments that glial cells have a variety of neuro-transmitter receptors on their membrane.Gilial cells can integrate synaptic information and are related to multi-neuron diseases.Based on the existing theoretical work,we investigate the coupling mechanism of astrocytes and neurons by theoretical and numerical method.By stimulating the astrocytes,we got the hyper-excitable state of the neuron,and hyper-excitability is an important feature of epilepsy.Then we analyze the effects of coupling strength on the system,and find that the coupling strength is the key factor leading the neuronal hyper-excitable.These results may give some suggestions when people try to find out the physiological mechanism of epilepsy.

关 键 词：星形胶质细胞 神经元超激发 三向突触 癫痫 

分 类 号：Q61[生物学—生物物理学]